AP4B1 Antibody

Datasheet

Code	CSB-PA897585LA01HU
Size	US$166
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Image	Western blot All lanes: AP4B1 antibody at 3μg/ml Lane 1: HepG2 whole cell lysate Lane 2: U251 whole cell lysate Lane 3: LO2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 84, 35 kDa Observed band size: 84 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA897585LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA897585LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) AP4B1 Polyclonal antibody

Uniprot No.

Q9Y6B7

Target Names

AP4B1

Alternative Names

AP4B1AP-4 complex subunit beta-1 antibody; AP-4 adaptor complex subunit beta antibody; Adaptor-related protein complex 4 subunit beta-1 antibody; Beta subunit of AP-4 antibody; Beta4-adaptin antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human AP-4 complex subunit beta-1 protein (201-500AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The AP4B1 Antibody (Product code: CSB-PA897585LA01HU) is Non-conjugated. For AP4B1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA897585LB01HU	AP4B1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA897585LC01HU	AP4B1 Antibody, FITC conjugated
Biotin	CSB-PA897585LD01HU	AP4B1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.

Gene References into Functions

Novel homozygous 2-bp deletion in AP4B1 was found in siblings with intellectual disability and spastic tetraplegia. PMID: 24781758
Data suggest that AP4B1 mutations cause spastic paraplegia type 47 and should be considered in early onset spastic paraplegia with intellectual disability. PMID: 22290197

Involvement in disease

Spastic paraplegia 47, autosomal recessive (SPG47)

Subcellular Location

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.

Protein Families

Adaptor complexes large subunit family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 572

OMIM: 607245

KEGG: hsa:10717

STRING: 9606.ENSP00000256658

UniGene: Hs.515048

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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