AP4M1 Antibody

Datasheet

Code	CSB-PA001883GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

O00189

Target Names

AP4M1

Alternative Names

Adapter-related protein complex 4 mu-1 subunit antibody; Adaptor related protein complex 4 mu 1 subunit antibody; Adaptor related protein complex AP 4 mu4 subunit antibody; Adaptor related protein complex AP4 mu4 subunit antibody; Adaptor-related protein complex AP-4; mu 1 antibody; AP 4 adapter complex mu subunit antibody; AP 4 complex subunit mu 1 antibody; AP-4 adapter complex mu subunit antibody; AP-4 complex subunit mu-1 antibody; AP4 adapter complex mu subunit antibody; AP4 complex subunit mu 1 antibody; AP4M1 antibody; AP4M1_HUMAN antibody; Ap4m4 antibody; CPSQ3 antibody; MU 4 antibody; Mu adaptin related protein 2 antibody; MU ARP2 antibody; Mu subunit of AP 4 antibody; Mu subunit of AP-4 antibody; Mu-adaptin-related protein 2 antibody; mu-ARP2 antibody; mu4 antibody; Mu4-adaptin antibody; MUARP 2 antibody; MUARP2 antibody; SPG50 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human AP4M1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.

Gene References into Functions

analysis of the AP4M1 mutation associated with aggressive behavior in addition to mild dysmorphic features, intellectual disability, spastic paraparesis and reduced head circumference [case report] PMID: 25496299
Results show that AP-4 can bind different types of cytosolic signals known to mediate basolateral transport in epithelial cells. Depletion of mu 4 results in the mis-sorting of several proteins in epithelial cells. PMID: 11802162
AP-4 protein complex is involved in the regulation of somatodendritic-specific distribution of its cargo proteins including AMPA receptors. PMID: 18341993
In all five patients with autosomal-recessive type of tetraplegic cerebral palsy with mental retardation, a donor splice site pathogenic mutation in intron 14 of the AP4M1 gene (c.1137+1G-->T), was identified. PMID: 19559397

Involvement in disease

Spastic paraplegia 50, autosomal recessive (SPG50)

Subcellular Location

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Early endosome.

Protein Families

Adaptor complexes medium subunit family

Tissue Specificity

Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung.

Database Links

HGNC: 574

OMIM: 602296

KEGG: hsa:9179

STRING: 9606.ENSP00000352603

UniGene: Hs.632317

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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