ARHGAP11B Antibody

Code CSB-PA664668LA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ARHGAP11B Polyclonal antibody
Uniprot No.
Target Names
ARHGAP11B
Alternative Names
ARHGAP11B antibody; FAM7B1 antibody; Rho GTPase-activating protein 11B antibody; Protein FAM7B1 antibody; Rho-type GTPase-activating protein 11B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Rho GTPase-activating protein 11B protein (99-231AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ARHGAP11B Antibody (Product code: CSB-PA664668LA01HU) is Non-conjugated. For ARHGAP11B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA664668LB01HU ARHGAP11B Antibody, HRP conjugated ELISA
FITC CSB-PA664668LC01HU ARHGAP11B Antibody, FITC conjugated
Biotin CSB-PA664668LD01HU ARHGAP11B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.
Gene References into Functions
  1. The data also demonstrate that a single C-->G base substitution underlies the ARHGAP11B-mediated basal progenitor amplification implicated in neocortex expansion. PMID: 27957544
  2. ARHGAP11B may have contributed to evolutionary expansion of human neocortex. PMID: 25721503
Subcellular Location
Mitochondrion matrix.
Database Links

HGNC: 15782

OMIM: 616310

KEGG: hsa:89839

STRING: 9606.ENSP00000392760

UniGene: Hs.659621

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