ARL4C Antibody

Datasheet

Code	CSB-PA002086GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P56559

Target Names

ARL4C

Alternative Names

ADP ribosylation factor like 4C antibody; ADP ribosylation factor like 7 antibody; ADP-ribosylation factor-like protein 4C antibody; ADP-ribosylation factor-like protein 7 antibody; ADP-ribosylation factor-like protein LAK antibody; Arl4c antibody; ARL4C_HUMAN antibody; ARL7 antibody; LAK antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human ARL4C

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,IHC

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.

Gene References into Functions

We demonstrate that ARL4C knockdown likely attenuates osteogenesis of hASCs through inhibition of the Wnt signaling pathway. These results provide new insights into the mechanisms of osteogenic differentiation and provide a potential molecular target for bone tissue engineering. PMID: 29432742
ARL4C is expressed due to hypomethylation in the 3'-UTR for certain types of cancers and that ARL4C methylation status is involved in squamous cell carcinoma cell function. PMID: 27835592
Arl4c as a novel Wnt signal target molecule that links epithelial tubulogenesis to tumourigenesis. PMID: 28053143
Results indicated that overexpression of Arl4c might contribute to the tumorigenesis and might play a pivotal role in the progression of CRC. PMID: 26756615
Arl4c is involved in tumorigenesis and might represent a novel therapeutic target for suppressing proliferation and invasion of colorectal and lung cancer cells. PMID: 25486429
Study shows that three related Arf-like GTPases Arl4a, Arl4c, and Arl4d, are able to recruit ARNO and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form. PMID: 17398095
ARL7 might modulate the intracellular vesicular transport via interaction with microtubules. PMID: 19409876

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Subcellular Location

Cell projection, filopodium. Cell membrane. Cytoplasm.

Protein Families

Small GTPase superfamily, Arf family

Tissue Specificity

Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta.

Database Links

HGNC: 698

OMIM: 604787

KEGG: hsa:10123

STRING: 9606.ENSP00000375057

UniGene: Hs.111554

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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