ARPP19 Antibody

Code CSB-PA348885LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA348885LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA348885LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ARPP19 Polyclonal antibody
Uniprot No.
Target Names
ARPP19
Alternative Names
ARP19 antibody; ARP19_HUMAN antibody; ARPP-19 antibody; Arpp19 antibody; cAMP-regulated phosphoprotein 19 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human cAMP-regulated phosphoprotein 19 protein (2-105AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ARPP19 Antibody (Product code: CSB-PA348885LA01HU) is Non-conjugated. For ARPP19 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA348885LB01HU ARPP19 Antibody, HRP conjugated ELISA
FITC CSB-PA348885LC01HU ARPP19 Antibody, FITC conjugated
Biotin CSB-PA348885LD01HU ARPP19 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.
Gene References into Functions
  1. Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A disinhibition. PMID: 28613156
  2. Study showed that ARPP-19 promoted both proliferation and metastasis of human glioma cells and the expression of ARPP-19 and CD147 in high-grade glioma was significantly higher than that in the low-grade glioma. PMID: 27380244
  3. Data show that micrRNA miR-320a directly targets cAMP-regulated phosphoprotein 19 (ARPP-19) and estrogen-related receptor gamma protein (ERRgamma) in breast cancer cell lines. PMID: 25736597
  4. ARPP-19 may play a role in HCC pathogenesis through regulating cell proliferation. PMID: 25547487
  5. ARPP19 gene expression is decreased in follicular variant of papillary thyroid carcinoma. PMID: 21509594
  6. Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease. PMID: 11771749

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Subcellular Location
Cytoplasm.
Protein Families
Endosulfine family
Database Links

HGNC: 16967

OMIM: 605487

KEGG: hsa:10776

STRING: 9606.ENSP00000249822

UniGene: Hs.512908

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