ASCC2 Antibody

Code CSB-PA296823
Size US$166
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  • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T cells, A431 cells, hepG2 cells, Primary antibody: CSB-PA296823(ASCC2 Antibody) at dilution 1/367, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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Product Details

Uniprot No.
Target Names
ASCC2
Alternative Names
1700011I11Rik antibody; 2610034L15Rik antibody; Activating signal cointegrator 1 complex subunit 2 antibody; AI482016 antibody; ASC 1 complex subunit p100 antibody; ASC-1 complex subunit p100 antibody; ASC1P100 antibody; ASCC 2 antibody; Ascc2 antibody; ASCC2_HUMAN antibody; AW046480 antibody; FLJ21588 antibody; OTTMUSP00000005258 antibody; p100 antibody; RGD1561422 antibody; RP23-280J3.3 antibody; Trip4 complex subunit p100 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide of Human ASCC2
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. As part of the ribosome quality control trigger (RQT) complex, recognizes ZNF598-dependent ubiquitination of stalled ribosomes.
Subcellular Location
Nucleus. Nucleus speckle.
Protein Families
ASCC2 family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 24103

OMIM: 614216

KEGG: hsa:84164

STRING: 9606.ENSP00000305502

UniGene: Hs.731754

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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