ATMIN Antibody

Datasheet

Code	CSB-PA002304ESR1HU
Size	US$166
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Image	Western blot All lanes: ATMIN antibody at 1.53μg/ml Lane 1: Hela whole cell lysate Lane 2: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 89, 73 kDa Observed band size: 89, 51 kDa Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA002304ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ATMIN Polyclonal antibody

Uniprot No.

O43313

Target Names

ATMIN

Alternative Names

ASCIZ antibody; ATM INteracting protein antibody; ATM interactor antibody; ATM substrate CHK2-interacting zinc finger protein antibody; ATM/ATR substrate CHEK2 interacting zinc finger protein antibody; ATM/ATR Substrate Chk2 Interacting Zn++ finger protein antibody; ATM/ATR substrate Chk2 interacting Zn2+ finger protein antibody; ATM/ATR-substrate CHK2-interacting zinc finger protein antibody; ATMIN antibody; ATMIN_HUMAN antibody; DKFZp779K1455 antibody; FLJ76795 antibody; KIAA0431 antibody; Zinc finger protein 822 antibody; ZNF 822 antibody; ZNF822 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human ATM interactor protein (160-360AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.

Gene References into Functions

The study results improve our understanding of the ATMIN-KRas axis leading to HNSCC migration or invasion and metastasis and facilitates the identification of possible therapy targets of downstream genes for designing effective therapeutic strategies in personalized medicine PMID: 28012797
ASCIZ/ATMIN is dispensable for ATM activation, and contradict the previously reported dependence of ATM on ASCIZ/ATMIN. PMID: 28648892
WRNIP1 connects PCNA monoubiquitination with ATMIN/ATM to activate ATM signalling in response to replication stress and contribute to the maintenance of genomic stability. PMID: 26549024
Studies suggest that ATM INteractor (ATMIN) could be an important biomarker in disease prognosis and treatment that might lighten the burden of chronic kidney disease and also affect on its progression. PMID: 27913685
Repression of ATMIN in hypoxia is mediated by both p53 and HIF-1alpha in an oxygen dependent manner. PMID: 26875667
ATMIN is required for cell cycle progression and chromosome segregation following replication stress.ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress. PMID: 25262557
The ASCIZ-DYNLL1 feedback loop represents a novel mechanism for auto-regulation of gene expression, where the gene product directly inhibits the transcriptional activator while bound at its own promoter. PMID: 22167198
these results imply a potential cellular interference between DYNLL1 and ATMIN functions. PMID: 21971545
Absence of Asciz (Atmin) leads to increased oxidative and methylating DNA base damage sensitivity in primary fibroblasts PMID: 20975950
Asciz (Atmin) deletion or knock-down does not affect ATM levels and activation in mouse, chicken, or human cells PMID: 20975950
ASCIZ acts as a lesion-specific focus scaffold in a Rad51-dependent pathway that resolves cytotoxic repair intermediates, most likely single-stranded DNA gaps, resulting from MLH1-dependent processing of base lesions. PMID: 15933716
ATMIN defines a novel NBS1-independent pathway of ATM signalling. PMID: 17525732
These data suggest that ASCIZ may affect the choice between competing base repair pathways in a manner that reduces the amount of substrates available for Ig gene conversion. PMID: 18433721
ASCIZ (ATMIN) is structurally related to the yeast ATM/ATR substrate Mdt1 (Pin4/Ybl051c); both proteins contain SQ/TQ cluster domains and interact with N-terminal FHA domains of CHK2/Rad53 kinases. PMID: 18728389
ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein (ASCIZ) required for repair of abasic sites after methylating and oxidative DNA damage but not double-strand breaks. Forms DNA damage-induced foci with RAD51 and ssDNA. ASCIZ foci depend on MLH1. PMID: 15933716

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Subcellular Location

Nucleus. Note=Nuclear, in discrete foci during G1 phase.

Tissue Specificity

Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle.

Database Links

HGNC: 29034

OMIM: 614693

KEGG: hsa:23300

STRING: 9606.ENSP00000299575

UniGene: Hs.16349

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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