ATRN Antibody

Code CSB-PA002435ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA002435ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA002435ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ATRN Polyclonal antibody
Uniprot No.
Target Names
ATRN
Alternative Names
ATRN antibody; ATRN_HUMAN antibody; attractin 2 antibody; Attractin antibody; DPPT L antibody; DPPT-L antibody; KIAA0548 antibody; Mahogany homolog antibody; mahogany protein antibody; Mahogany, mouse, homolog of antibody; MGCA antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Attractin protein (84-350AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system.
Gene References into Functions
  1. ATRN encodes Attractin, which was previously shown to play a critical role in central myelination PMID: 28493104
  2. Data indicate that Attractin was involved in male reproduction in both human and BALB/c mice, but it exerted a different expression profile in different species. PMID: 25318887
  3. The levels of both dipeptidyl-peptidase 4 and attractin in circulating monocytes were significantly higher in obese subjects as compared with levels in lean controls or in subjects with type 2 diabetes. PMID: 20198559
  4. associated with spermatozoa PMID: 19535787
  5. This protein is isolated from human blood and characterized. PMID: 12675230
  6. It is the first time expression of attractin on monocytes and provide first data suggesting that drugs directed to DP IV-like enzyme activity could affect monocyte function via attractin inhibition. PMID: 16835316
  7. The product of the murine "Mahogany" gene controls energy metabolism and is the murine orthologof human membrane attractin. PMID: 10086355
  8. Through use of PCR from hamster-human somatic cell hybrids, localizes the EST AB011120 (KIAA0548) to human chromosome 20p13. AB011120 encodes the central to 3' UTR of the membrane form of human attractin. PMID: 9628581
  9. The product of the murine "Mahogany" locus, controlling agouti-mediated melanocyte pigmentation and control of energy metabolism, is the murine ortholog of human attractin. PMID: 10086356
  10. Provides the genomic basis for production of a soluble and membrane form of attractin by alternative splicing. In the process, by sequencing from positionally-determined BAC clones, confirms the localization of attractin to chromosome 20p13. PMID: 10811918

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Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
Tissue Specificity
Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in
Database Links

HGNC: 885

OMIM: 603130

KEGG: hsa:8455

STRING: 9606.ENSP00000262919

UniGene: Hs.276252

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