B3GALNT2 Antibody

Datasheet

Code	CSB-PA002489GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q8NCR0

Target Names

B3GALNT2

Alternative Names

3-GalNAc-T2 antibody; 3-N-acetylgalactosaminyltransferase 2 antibody; 3-N-acetylgalactosaminyltransferase II antibody; B3GalNAc T2 antibody; B3GalNAcT2 antibody; b3galnt2 antibody; B3GL2_HUMAN antibody; Beta 1,3 galactosaminyltransferase 2 antibody; Beta 1,3 N acetylgalactosaminyltransferase 2 antibody; Beta 1,3 N acetylgalactosaminyltransferase II antibody; Beta 1,3 N acetylgalactosaminyltransferase II MGC39558 antibody; Beta 3 GalNAc T2 antibody; Beta-1 antibody; beta-1,3-GalNAc-T2 antibody; Beta3GalNAcT2 antibody; MDDGA11 antibody; MGC39558 antibody; UDP GalNAc:betaGlcNAc beta 1,3 galactosaminyltransferase polypeptide 2 antibody; UDP-GalNAc:beta-1 antibody; UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human B3GALNT2

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.

Gene References into Functions

Mutations in B3GALNT2 give rise to a novel muscular dystrophy-dystroglycanopathies syndrome presentation, characterized by intellectual disability and seizure, but without any apparent muscular involvement. PMID: 29273094
B3GALNT2 is a gene associated with congenital muscular dystrophy with brain malformations. PMID: 24084573
B3GALNT2 overexpression is associated with breast cancer. PMID: 24285400
Results demonstrate a role for B3GALNT2 in the glycosylation of alpha-DG and show that B3GALNT2 mutations can cause dystroglycanopathy with muscle and brain involvement. PMID: 23453667
Although the GalNAcbeta1-3GlcNAcbeta1-R structure has not been reported in humans or other mammals, we have discovered a novel human glycosyltransferase producing this structure on N- and O-glycans. PMID: 14724282

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Involvement in disease

Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A11 (MDDGA11)

Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum.

Protein Families

Glycosyltransferase 31 family

Tissue Specificity

Expressed in all tissues examined, but at highest levels in testis, adipose tissue, skeletal muscle and ovary.

Database Links

HGNC: 28596

OMIM: 610194

KEGG: hsa:148789

STRING: 9606.ENSP00000355559

UniGene: Hs.498143

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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