BAIAP2L1 Antibody

1. Rho family GTPases use the I-BAR proteins, IRSp53 (also known as BAIAP2), IRTKS and Pinkbar, as a central mechanism to modulate cell morphology. PMID: 27278019
2. IRTKS promoted serum-induced cell migration along with enhanced phosphorylation of mitogen activated kinases Erk1/2 and p38, and activation of small GTPases Rac1 and Cdc42. In addition, cells overexpressing IRTKS exhibited an increased polarity characterized by elongated cytoplasm and extensive lamellipodia at leading edges. PMID: 27693783
3. Upregulation of BAIAP2L1 is associated with ovarian cancer. PMID: 26222696
4. Lacking the Bin-Amphiphysin-Rvs (BAR) dimerization domain of BAIAP2L1. PMID: 25589496
5. IRTKS can interact with epidermal growth factor receptor (EGFR), results in the phosphorylation of extracellular signal-regulated kinase PMID: 23693078
6. Identification of a novel oncogenic FGFR3-BAIAP2L1 fusion protein in bladder cancer. PMID: 23175443
7. These data suggest that IRTKS is a novel regulator of p53, modulating low level of MDM2-mediated p53 ubiquitination in unstressed cells. PMID: 21887275
8. data suggest Src-stimulated IRTKS phosphorylation is essential for its function in cell motility PMID: 21840312
9. Results describe the NMR structure of insulin receptor tyrosine kinase substrate (IRTKS) SH3 domain in complex with a repeat from Escherichia coli-secreted protein F-like protein encoded on prophage U (EspF(U)). PMID: 21098279
10. Study characterised IRTKS, which has widespread tissue distribution, is a substrate for the insulin receptor and binds Rac, and expression of IRTKS induces clusters of short actin bundles rather than filopodia-like protrusions. PMID: 17430976
11. Screening of the mammalian SH3 proteome for the ability to bind EspF(U) identified the SH3 domain of insulin receptor tyrosine kinase substrate (IRTKS), a factor known to regulate the cytoskeleton. PMID: 19366662

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HGNC: 21649

OMIM: 611877

KEGG: hsa:55971

STRING: 9606.ENSP00000005260

UniGene: Hs.656063