BORA Antibody

Datasheet

Code	CSB-PA750873LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Jurkat whole cell lysate, SH-SY5Y whole cell lysate All lanes: BORA antibody at 4.8µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 62, 54 kDa Observed band size: 62 kDa IHC image of CSB-PA750873LA01HU diluted at 1:300 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BORA Polyclonal antibody

Uniprot No.

Q6PGQ7

Target Names

BORA

Alternative Names

Aurora borealis antibody; bora antibody; bora; aurora kinase A activator antibody; BORA_HUMAN antibody; C13orf34 antibody; Chromosome 13 open reading frame 34 antibody; FLJ22624 antibody; HsBora antibody; Protein aurora borealis antibody; RP11-342J4.2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein aurora borealis protein (178-312AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The BORA Antibody (Product code: CSB-PA750873LA01HU) is Non-conjugated. For BORA Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA750873LB01HU	BORA Antibody, HRP conjugated	ELISA
FITC	CSB-PA750873LC01HU	BORA Antibody, FITC conjugated
Biotin	CSB-PA750873LD01HU	BORA Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Required for the activation of AURKA at the onset of mitosis.

Gene References into Functions

our findings demonstrated that Bora was overexpressed and served as an independent biomarker for poor prognosis in multiple adenocarcinomas. PMID: 28402276
the mechanism of Plk1 activation and the potential role of Bora phosphorylation by Cdk1, is reported. PMID: 27831827
These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry. PMID: 27068477
Bora was found to play a significant role in radiosensitivity through the regulation of MDC1 and DNA repair. PMID: 25742493
Activation of Plk1 by Aurora-A may function as a bistable switch PMID: 24338364
Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex. PMID: 23970419
Following UV irradiation, ataxia telangiectasia-mutated- and Rad3-related protein phosphorylates Bora at Thr-501. The phosphorylated Thr-501 is subsequently recognized by the E3 ubiquitin ligase SCF-beta-TRCP, which targets Bora for degradation. PMID: 23592782
Study concludes that tight regulation of the Bora protein by its synthesis and degradation is critical for cell cycle progression. PMID: 18378770
study reports that the synergistic action of Bora & the kinase Aurora A controls G2-M transition; Bora accumulates in G2 phase & promotes Aur-A-mediated activation of Polo-like kinase 1, leading to activation of cyclin-dependent kinase 1 & mitotic entry PMID: 18566290
Recent advances in the understanding of the functional crosstalk between Plk1 and Aurora-A before and during mitosis. PMID: 19487276

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Protein Families

BORA family

Database Links

HGNC: 24724

OMIM: 610510

KEGG: hsa:79866

STRING: 9606.ENSP00000375082

UniGene: Hs.643464

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