BRK1 Antibody

Datasheet

Code	CSB-PA200670
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA200670(BRK1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA200670(BRK1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A172 cells, Primary antibody: CSB-PA200670(BRK1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8WUW1

Target Names

BRK1

Alternative Names

BRK1 antibody; C3orf10 antibody; HSPC300 antibody; MDS027 antibody; Protein BRICK1 antibody; BRK1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human BRK1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.

Gene References into Functions

Sp1 transcriptionally regulates BRK1 expression in non-small cell lung cancer cells. PMID: 24680773
Data show that Brk1 downregulation results in defective directional migration and invasive growth in renal cell carcinoma cells as well as in other tumor cell types. PMID: 20861187
Von Hippel-Lindau (VHL) locus deletion of the HSPC300 actin regulator gene greatly lowers risk of clear cell renal cell carcinoma development in Spanish VHL syndrome patients studied. PMID: 17311301
higher expression in primary lung tumours with lymph node metastases and also in tumours from patients with more advanced disease PMID: 19576655
Growing body of evidence suggesting that patients with VHL syndrome caused by large VHL deletions that include C3orf10 may be designated as having a specific subtype (Type 1B) of the disorder. PMID: 19764026

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Subcellular Location

Cytoplasm, cytoskeleton.

Protein Families

BRK1 family

Database Links

HGNC: 23057

OMIM: 611183

KEGG: hsa:55845

STRING: 9606.ENSP00000432472

UniGene: Hs.649307

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Regulation of actin cytoskeleton

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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