BRWD3 Antibody

Code CSB-PA008526
Size US$100
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Product Details

Uniprot No.
Target Names
BRWD3
Alternative Names
BRWD3Bromodomain and WD repeat-containing protein 3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of Human BRWD3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Gene References into Functions
  1. BCL7A, BRWD3, and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations. PMID: 29166413
  2. A nonsense mutation in BRWD3 in a family with X-linked intellectual disability associated with macrocephaly. PMID: 24462886
  3. potential serological biomarker of breast cancer PMID: 22024541
  4. Includes the identification of truncating mutations in this gene that segregated with mental retardation in the families tested. PMID: 19377476
  5. BRWD3 is therefore a new gene implicated in the etiology of XLMR associated with macrocephaly and may cause disease by altering intracellular signaling pathways affecting cellular proliferation. PMID: 17668385

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Involvement in disease
Mental retardation, X-linked 93 (MRX93)
Tissue Specificity
Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined.
Database Links

HGNC: 17342

OMIM: 300553

KEGG: hsa:254065

STRING: 9606.ENSP00000362372

UniGene: Hs.147027

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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