Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) C1QBP Polyclonal antibody

Uniprot No.

Q07021

Target Names

C1QBP

Alternative Names

ASF/SF2 associated protein p32 antibody; C1q globular domain binding protein antibody; C1qBP antibody; C1QBP_HUMAN antibody; Complement component 1 q subcomponent binding protein antibody; Complement component 1 Q subcomponent binding protein mitochondrial antibody; Complement component 1 Q subcomponent-binding protein; mitochondrial antibody; GC1Q R antibody; GC1q R protein antibody; GC1q-R protein antibody; GC1QBP antibody; GC1QR antibody; globular domain of; C1q; receptor for antibody; Glycoprotein gC1qBP antibody; HABP 1 antibody; HABP1 antibody; Hyaluronan binding protein 1 antibody; Hyaluronan-binding protein 1 antibody; Mitochondrial matrix protein p32 antibody; p32 antibody; p32 splicing factor antibody; p33 antibody; Pre mrna splicing factor SF2 P32 subunit precursor antibody; SF2p32 antibody; Splicing factor SF2 associated protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from internal of Human C1QBP.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

Target Background

Function

Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection.; (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA.; (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A.; (Microbial infection) Involved in replication of Rubella virus.

Gene References into Functions

these results demonstrate that host-derived p32 has an important immunomodulating function that helps to counterbalance an overwhelming danger-associated molecular patterns response PMID: 29035880
We propose that endogenous gC1qR/p33 physically interacts with MCP-1 causing stabilization of the MCP-1 protein and stimulation of its activity in human periodontal ligament cells, suggesting a novel gC1qR/p33-mediated pro-inflammatory mechanism of action. PMID: 29358188
C1QBP may regulate L1CAM expression in renal cell carcinoma (RCC) through the Wnt/beta-Catenin pathway, thus affecting RCC cell adhesion, migration and metastasis. PMID: 28428626
Hepatitis C virus core protein ligates gC1qR to induce A20 expression in macrophages via P38, JNK and NF-kappaB signaling pathways, which leads to a low-grade chronic inflammation during HCV infection. PMID: 27183919
The RAP80 deficiency reduces the protein level of p32 and p32 dependent mitochondrial translating proteins such as Rieske and COX1. PMID: 28842250
Mutation in C1QBP gene is associated with Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies. PMID: 28942965
results implicate p32 as a key host factor for RSV virus production, and bring to light the potential importance of mitochondria in RSV infection PMID: 28576489
single nucleotide polymorphism srs2285747 of HABP1 increased breast cancer risk and elevated its protein expression in northern Chinese women PMID: 28108744
The authors identified Importin-alpha1 to bind to Coxiella burnetii AnkG and concluded that binding of AnkG to p32 and Importin-alpha1 is essential for its migration into the nucleus. PMID: 27328359
HABP1 overexpression is associated with cervical cancer. PMID: 28039537
This study supports a key role for gC1qR in malaria-associated endovascular pathogenesis PMID: 27835682
these data suggest that C1QBP could regulate YBX1 to suppress the AR-enhanced RCC cell invasion. Targeting this newly identified C1QBP/YBX1/AR/MMP9 signal pathway may provide a new potential therapy to better suppress RCC metastasis. PMID: 28107702
C1QBP interacts with DLAT and regulates the enzyme activity of pyruvate dehydrogenase. PMID: 26753982
Sp1-ZNF32-C1QBP axis protects against oxidative stress/apoptosis in hepatocellular carcinoma cells. PMID: 26497555
Findings highlight a cytoprotective role of p32 under starvation conditions by regulating ULK1 stability, and uncover a crucial role of the p32-ULK1-autophagy axis in coordinating stress response, cell survival and mitochondrial homeostasis. PMID: 25909887
p32 appeared to be a core component of herpesvirus nuclear egress complexes, like UL31 and UL34 homologs in other herpesviruses, and to play multiple roles in herpesvirus nuclear egress. PMID: 26085152
data suggest that C1QBP is a novel regulator of YBX1, and the expression of C1QBP and the nuclear expression of YBX1 could both be used as independent prognostic makers for cancer progression in the RCC patients PMID: 25497084
Data show that p32 hyaluronan binding protein (p32) is a direct transcriptional target of oncogene Myc and that high level of Myc in malignant brain cancers correlates with high expression of p32. PMID: 25528767
HABP1 protein high expression may contribute to the tumor progression and poor prognosis of TNBC, especially in predicting prognosis in TNBCs without lymph node metastasis. PMID: 25794640
our findings suggest that the C1QBP protein could be a potential proliferative marker in breast cancer PMID: 25573962
Our results indicated that overexpression of HABP1 may serve as a new biomarker to predict the progression and prognosis of endometrial cancer. PMID: 25355598
Interaction between HSV-1 ICP34.5 and p32 leads to the disintegration of nuclear lamina and facilitates the nuclear egress of HSV-1 particles. PMID: 25355318
This suggests the importance of HABP1 induced HA cable formation in enhancing tumor potency by maintaining the oxidant levels and subsequent autophagic vacuolation. PMID: 25061661
The data suggest that p32 expression is important for trophoblast proliferation, via a mechanism involving regulation of normal mitochondrial function. PMID: 24874554
By binding to p32, Mcl-1 can interfere with the uniporter function, thus inhibit the mitochondrial Ca(2+) uploading. This may provide a novel mechanism to explain the anti-apoptotic function of Mcl-1. PMID: 25091479
C1QBP was observed to be overexpressed in breast cancer tissues, and its expression level was closely linked with distant metastasis and TNM stages. PMID: 23924515
RNase H1 and protein P32 are involved in mitochondrial pre-rRNA processing PMID: 23990920
Data indicate that hyaluronic acid binding protein 1 (HABP1)/P32/C1QBP overexpression correlated with peritoneal dissemination and lymph node metastasis in EOC. PMID: 23929393
this data suggest a novel protective mechanism of p33 in modulating innate immune response by neutralizing cytotoxic AMPs at the host cell surface. PMID: 24174616
Studies highlight the critical contributions of the p32 protein to the morphology of mitochondria and ER under normal cellular conditions, as well as important roles of the p32 protein in cellular metabolism and various stress responses. PMID: 23692256
in ovarian serous carcinoma, HABP1 overexpression was correlated to histological-differentiation, residual tumor-size, serum CA-125 and stage; increased expression associated with cisplatin resistance; HAPBP1 overexpression in primary ovarian carcinomas is related to decrease in overall survival and progression free survival PMID: 22771308
polymorphisms in HABP1 are potentially involved in glaucomatous neurodegeneration. PMID: 22960332
C1q/gC1qR may regulate dendritic cells differentiation and function through the DC-SIGN-mediated induction of cell-signaling pathways. PMID: 22700724
C1qbp is upregulated in human lung and colon cancer cell lines and tumors. PMID: 22101277
p32 is a new rRNA maturation factor involved in the remodeling from pre-90S particles to pre-40S and pre-60S particles that requires the exchange of FBL for Nop52. PMID: 21536856
we have identified a mitochondrial protein p32 as a novel interactor of parkin in the brain PMID: 22008525
gC1qR could play an important role in HPV-16-induced cervical cancer immune evasion depending on its level of expression and subcellular localisation. PMID: 21725590
HABP1 interacts with cell surface receptor integrin alphaVbeta3 that induces cell migration and tumor growth mediated by transcription factor NF-kappa B, membrane type-1 matrix metalloproteinase and matrix metalloprotease-2. PMID: 21627988
there is a a role for platelet-mediated clumping, rosetting and adhesion to gC1qR in the pathogenesis of severe malaria PMID: 21559373
cell-surface gC1qR regulates lamellipodia formation and metastasis via receptor tyrosine kinase activation. PMID: 21536672
The data presented suggest that p32 fulfills an essential function for rubella virus replication in directing trafficking of mitochondria near sites of viral replication to meet the energy demands of the virus. PMID: 21248045
the potential of p32 for antibody-based tumor targeting strategies and the utility of the 2.15 antibody as targeting moiety for the selective delivery of imaging and therapeutic agents to tumors. PMID: 21156793
p32 is highly expressed in prostate tumor samples and its expression is significantly associated with the Gleason score, pathological stage and relapse PMID: 21205079
Knocking down p32 expression in human cancer cells strongly shifts their metabolism from oxidative phosphorylation (OXPHOS) to glycolysis. PMID: 20100866
Cryoglobulins were present in over 90% of Chikungunya infection patients. Cryoglobulin frequency and levels decreased with time in recovering patients. PMID: 19190731
increase in expression over the rostral portion of the sperm head after capacitation; may play a role in human fertilization PMID: 11870091
demonstrate that MT1-MMP via its cytoplasmic tail directly associates with a chaperone-like compartment-specific regulator gC1qR PMID: 12220632
presence of homologous sequences of HABP1 cDNA, termed processed HABP1 pseudogene, in humans PMID: 12443542
Maturation-dependent expression of this protein in monocyte-derived dendritic cells. PMID: 12538033
gC1qR expressed on activated platelets may contribute directly to thrombosis, inflammation, and endovascular infections. PMID: 12574814

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Subcellular Location

Mitochondrion matrix. Nucleus. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Cytoplasm. Nucleus, nucleolus. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes.

Protein Families

MAM33 family

Tissue Specificity

Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells.

Database Links

HGNC: 1243

OMIM: 601269

KEGG: hsa:708

STRING: 9606.ENSP00000225698

UniGene: Hs.555866

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Code	CSB-PA081203
Size	US$297
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Image	Western blot analysis of extracts from Jurkat cells, K562 cells and HUVEC cells, using C1QBP antibody. Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using C1QBP antibody.
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C1QBP Antibody

Product Details

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Target Background