CA5A Antibody

Code CSB-PA056143
Size US$297
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  • Western blot analysis of extracts from A549 cells, LOVO cells and K562 cells, using CA5A antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CA5A Polyclonal antibody
Uniprot No.
Target Names
CA5A
Alternative Names
CA5A antibody; CA5Carbonic anhydrase 5A antibody; mitochondrial antibody; EC 4.2.1.1 antibody; Carbonate dehydratase VA antibody; Carbonic anhydrase VA antibody; CA-VA antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human CA5A.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Reversible hydration of carbon dioxide. Low activity.
Gene References into Functions
  1. In 10 of 96 patients, mutations in CA5A were identified on both alleles but none in CA5B. Exhibiting decreased enzyme activity or thermal stability, all CAVA mutations were proven to cause disease, whereas the three variants showed no relevant effect PMID: 26913920
  2. CA5A alterations cause hyperammonemia in early childhood that result in mitochondrial carbonic anhydrase VA deficiency PMID: 24530203
  3. activators enhanced kcat, with no effect on KM, favoring the RDS in the catalytic cycle; the activation pattern of the two mitochondrial isoforms is very different from each other and as compared to those of the cytosolic isoforms hCA I and II. PMID: 17174092
Involvement in disease
Hyperammonemia due to carbonic anhydrase VA deficiency (CA5AD)
Subcellular Location
Mitochondrion.
Protein Families
Alpha-carbonic anhydrase family
Database Links

HGNC: 1377

OMIM: 114761

KEGG: hsa:763

STRING: 9606.ENSP00000309649

UniGene: Hs.177446

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