CABLES1 Antibody

1. We have identified four potentially pathogenic missense CABLES1 variants as a novel, although infrequent, cause of Cushing's Disease in children and young adults. PMID: 28533356
2. miR199a-3p and P53 are coupled through CABLES1 and comprise a novel negative feedback loop that likely contributes to cardiac c-kit(+) cell proliferation and apoptosis. PMID: 28583208
3. Cables1/p21 pathway has a strong effect on the induction of cell senescence and inhibition of cell growth, and acts as a novel regulatory mechanism in which p21 is probably one of several downstream effector molecules to mediate Cables1. PMID: 28118639
4. CABLES1 is a critical regulator of corticotrope proliferation that defines a pathway often inactivated in Cushing disease PMID: 26695862
5. the results suggest Cables1 as a novel p21 regulator through maintaining p21 stability and support the model that the tumor-suppressive function of Cables1 occurs at least in part through enhancing the tumor-suppressive activity of p21. PMID: 24975575
6. Results illuminated a dynamic regulatory system through which activated Akt and 14-3-3 work directly together to neutralize a potent tumor suppressor function of Cables1. PMID: 25361894
7. The results did not detect a significant association. It indicated that common genetic variations in CDK5 genes might not play a role in the genetic predisposition to autism. PMID: 21890215
8. Analysis of the RT-PCR prducts of the CABLES1 gene showed eight intragenic deletions in its mRNA transcripts; 5/8 are the result of RNA splicing. PMID: 16177568
9. Loss of Cables expression in 65% of CRCs suggests that it is a common event in colonic carcinogenesis, with promoter methylation and LOH appearing to be important mechanisms of Cables gene inactivation. PMID: 17982127
10. Mechanisms of CABLES1 gene inactivation in ovarian cancer development are reported. PMID: 18059193

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HGNC: 25097

OMIM: 609194

KEGG: hsa:91768

STRING: 9606.ENSP00000256925

UniGene: Hs.11108