CACNB4 Antibody

Code CSB-PA004414LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA004414LA01HU at dilution of 1:100

  • Immunofluorescent analysis of PC-3 cells using CSB-PA004414LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CACNB4 Polyclonal antibody
Uniprot No.
Target Names
CACNB4
Alternative Names
CAB4 antibody; CACB4_HUMAN antibody; Cacnb4 antibody; CACNLB4 antibody; Calcium channel voltage dependent beta 4 subunit antibody; Calcium channel voltage dependent subunit beta 4 antibody; Calcium channel voltage-dependent subunit beta 4 antibody; Dihydropyridine sensitive L type calcium channel beta 4 subunit antibody; EA5 antibody; EIG9 antibody; EJM antibody; EJM4 antibody; EJM6 antibody; Voltage-dependent L-type calcium channel subunit beta-4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Voltage-dependent L-type calcium channel subunit beta-4 protein (1-217AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CACNB4 Antibody (Product code: CSB-PA004414LA01HU) is Non-conjugated. For CACNB4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA004414LB01HU CACNB4 Antibody, HRP conjugated ELISA
FITC CSB-PA004414LC01HU CACNB4 Antibody, FITC conjugated
Biotin CSB-PA004414LD01HU CACNB4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Gene References into Functions
  1. The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated. PMID: 24875574
  2. Genome-wide association studies identify CACNB4 mutation releated to juvenile myoclonic epilepsy. PMID: 23756480
  3. Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy PMID: 22892567
  4. The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif. PMID: 21220418
  5. CACNB4 is associated with acute lung injury in mice PMID: 21297076
  6. The novel nucleotide substitution T87C (D29D)in CACNB4 was observed in 2 migrainous vertigo patients and was not present in control DNA samples. PMID: 16866717
  7. No pathogenic mutation were identified in CACNB4. PMID: 18446307
  8. plays a role in neurotransmitter release. PMID: 18712068

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Involvement in disease
Epilepsy, idiopathic generalized 9 (EIG9); Juvenile myoclonic epilepsy 6 (EJM6); Episodic ataxia 5 (EA5)
Protein Families
Calcium channel beta subunit family
Tissue Specificity
Expressed predominantly in the cerebellum and kidney.
Database Links

HGNC: 1404

OMIM: 601949

KEGG: hsa:785

STRING: 9606.ENSP00000438949

UniGene: Hs.120725

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