CADM3 Antibody

Datasheet

Code	CSB-PA004427LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA004427LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA004427LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot Positive WB detected in: Rat stomach tissue, Mouse kidney tissue All lanes: CADM3 antibody at 3μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 44, 48, 39 kDa Observed band size: 44 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CADM3 Polyclonal antibody

Uniprot No.

Q8N126

Target Names

CADM3

Alternative Names

BIgR antibody; Brain immunoglobulin receptor antibody; CADM 3 antibody; cadm3 antibody; CADM3_HUMAN antibody; Cell adhesion molecule 3 antibody; Dendritic cell nectin like protein 1 short isoform antibody; FLJ10698 antibody; IgSF4B antibody; Immunoglobulin superfamily member 4B antibody; Necl 1 antibody; Necl-1 antibody; NECL1 antibody; Nectin like 1 antibody; Nectin like protein 1 antibody; Nectin-like protein 1 antibody; Synaptic cell adhesion molecule 3 antibody; synCAM3 antibody; TSLC1 like 1 antibody; TSLC1 like protein 1 antibody; TSLC1-like protein 1 antibody; TSLL1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human Cell adhesion molecule 3 protein (140-328AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CADM3 Antibody (Product code: CSB-PA004427LA01HU) is Non-conjugated. For CADM3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004427LB01HU	CADM3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004427LC01HU	CADM3 Antibody, FITC conjugated
Biotin	CSB-PA004427LD01HU	CADM3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.

Gene References into Functions

CADM3 expression was increased in retinoblastoma tissues and cells. miR-140-5p inhibited CADM3 expression possibly by targeting the 3'-UTR. PMID: 29808799
Nectin-based cell-cell adhesion was formed at the apical side of the junctional adhesion molecule (JAM)-based cell-cell adhesion; cadherin and claudin were recruited to the nectin-3 and JAM-based cell-cell adhesion sites to form AJ- and TJ-like domains. PMID: 24112238
NECL1 can inhibit the migration and invasion of glioma cells and induce differentiation. PMID: 20078932
Findings clearly reveal the structural basis for the cis-dimerization of nectins through the first Ig-like domains. PMID: 21325282
A link might exist between NECL1 and the extracellular matrix protein OPN in inhibiting the migration and invasion of U251 glioma ce PMID: 20598232
NECL1 may inhibit the proliferation of T98G cells by inducing its apoptosis. PMID: 18686605
Nec- 1 suppress the growth and tumorigenic ability of colon cancer cells. PMID: 19565570
Necl-1 is a neural-tissue-specific Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which potentially has membrane-associated guanylate kinase subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites PMID: 15741237
crystallographic analysis of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule PMID: 16467305
human NECL1 is an N-linked glycoprotein with a single glycosylation site at position N290KS PMID: 18420026
Expression of entry receptors nectin-1 and HVEM prevent entry of HSV-1 into human conjunctival epithelium. PMID: 18502984
suggests that NECL1 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation PMID: 19062177

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction.

Protein Families

Nectin family

Tissue Specificity

Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.

Database Links

HGNC: 17601

OMIM: 609743

KEGG: hsa:57863

UniGene: Hs.365689

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Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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