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CAPN7 Antibody

Datasheet
Code CSB-PA004500GA01HU
Size $600
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Product Details

Uniprot No.
Q9Y6W3
Target Names
CAPN7
Alternative Names
CAPN7 antibody; PALBHCalpain-7 antibody; EC 3.4.22.- antibody; PalB homolog antibody; PalBH antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human CAPN7
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Calcium-regulated non-lysosomal thiol-protease.
Gene References into Functions
  1. The proteolytic activity of CAPN7 is important for the acceleration of EGFR degradation via the endosomal sorting pathway. PMID: 24953135
  2. Data indicate that CAPN 7 promotes endometrial stromal cell (hESC) migration and invasion by increasing the activity of MMP-2 via an increased ratio of MMP-2 to TIMP-2. PMID: 23855590
  3. Mutational analysis of calpain-7 reveals the importance of not only the N-terminal microtubule-interacting and trafficking domains but also the C-terminal C2 domain-like domains for proteolytic activity. PMID: 23497113
  4. The detected enhancement of autolysis of mGFP-fused calpain-7 by coexpression with CHMP1B and observed further activation by additional coexpression of IST1 in HEK293T cells. PMID: 21616915
  5. Results demonstrate that human calpain 7 is proteolytically active, and imply that calpain 7 is activated by ESCRT-III-related protein IST1. PMID: 20849418

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Subcellular Location
Nucleus.
Protein Families
Peptidase C2 family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 1484

OMIM: 606400

KEGG: hsa:23473

STRING: 9606.ENSP00000253693

UniGene: Hs.595234

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