CCDC106 Antibody

Code CSB-PA961263
Size US$297
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  • Western blot analysis of extracts from Jurkat cells using Coiled-coil domain-containing protein 106 antibody and the same antibody preincubated with blocking peptide.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CCDC106 Polyclonal antibody
Uniprot No.
Target Names
CCDC106
Alternative Names
CC106_HUMAN antibody; Ccdc106 antibody; Coiled-coil domain-containing protein 106 antibody; HSU79303 antibody; Protein predicted by clone 23882 antibody; ZNF581 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence around aa.2~6 (N-D-R-S-S) derived from Human Coiled-coil domain-containing protein 106.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
Gene References into Functions
  1. Our studies revealed that CCDC106 is associated with non-small cell lung cancer progression and unfavorable prognosis. CCDC106 enhanced Cyclin A2 and Cyclin B1 expression and promoted A549 and H1299 cell proliferation, which depended on AKT signaling. These results suggest that CCDC106 may be a novel target for lung cancer treatment. PMID: 28460455
  2. CCDC106 promotes the degradation of p53 protein and inhibits its transactivity. PMID: 20159018
Subcellular Location
Nucleus. Note=Colocalizes with p53/TP53.
Database Links

HGNC: 30181

OMIM: 613478

KEGG: hsa:29903

UniGene: Hs.82482

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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