Recombinant Human Coiled-coil domain-containing protein 106 (CCDC106)

Code CSB-YP863135HU
MSDS
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Source Yeast
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Code CSB-EP863135HU
MSDS
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Source E.coli
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Code CSB-EP863135HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP863135HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP863135HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CCDC106
Uniprot No.
Alternative Names
CC106_HUMAN; Ccdc106; Coiled-coil domain-containing protein 106; HSU79303; Protein predicted by clone 23882; ZNF581
Species
Homo sapiens (Human)
Expression Region
1-280
Target Protein Sequence
MNDRSSRRRT MKDDETFEIS IPFDEAPHLD PQIFYSLSPS RRNFEEPPEA ASSALALMNS VKTQLHMALE RNSWLQKRIE DLEEERDFLR CQLDKFISSA RMEAEDHCRM KPGPRRMEGD SRGGAGGEAS DPESAASSLS GASEEGSASE RRRQKQKGGA SRRRFGKPKA RERQRVKDAD GVLCRYKKIL GTFQKLKSMS RAFEHHRVDR NTVALTTPIA ELLIVAPEKL AEVGEFDPSK ERLLEYSRRC FLALDDETLK KVQALKKSKL LLPITYRFKR
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
Gene References into Functions
  1. Our studies revealed that CCDC106 is associated with non-small cell lung cancer progression and unfavorable prognosis. CCDC106 enhanced Cyclin A2 and Cyclin B1 expression and promoted A549 and H1299 cell proliferation, which depended on AKT signaling. These results suggest that CCDC106 may be a novel target for lung cancer treatment. PMID: 28460455
  2. CCDC106 promotes the degradation of p53 protein and inhibits its transactivity. PMID: 20159018
Subcellular Location
Nucleus. Note=Colocalizes with p53/TP53.
Database Links

HGNC: 30181

OMIM: 613478

KEGG: hsa:29903

UniGene: Hs.82482

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