CD300LF Antibody

Datasheet

Code	CSB-PA819470LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA819470LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA819470LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CD300LF Polyclonal antibody

Uniprot No.

Q8TDQ1

Target Names

CD300LF

Alternative Names

CD300 antigen like family member antibody; CD300 antigen-like family member F antibody; CD300 molecule like family member f antibody; CD300f antibody; CD300LF antibody; CLM antibody; CLM-1 antibody; CLM1 antibody; CLM1_HUMAN antibody; CMRF35-like molecule 1 antibody; IGSF antibody; IgSF13 antibody; Immune receptor expressed on myeloid cells 1 antibody; immune receptor expressed on myeloid cells antibody; immunoglobin superfamily member antibody; Immunoglobulin superfamily member 13 antibody; Immunoglobulin superfamily member antibody; Inhibitory receptor IREM1 antibody; IREM antibody; IREM-1 antibody; IREM1 antibody; Nepmucin antibody; NK inhibitory receptor antibody; NKIR antibody; TREM antibody; triggering receptors expressed on myeloid cells antibody; UNQ3105/PRO10111 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human CMRF35-like molecule 1 protein (20-156AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CD300LF Antibody (Product code: CSB-PA819470LA01HU) is Non-conjugated. For CD300LF Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA819470LB01HU	CD300LF Antibody, HRP conjugated	ELISA
FITC	CSB-PA819470LC01HU	CD300LF Antibody, FITC conjugated
Biotin	CSB-PA819470LD01HU	CD300LF Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.

Gene References into Functions

this study demonstrates the role of CD300f in governing innate immune eosinophil activities in pediatric Crohn's disease patients and in active ulcerative colitis patients PMID: 27118491
findings suggest that two rare heterozygous truncating variations (RPS24 Q191X and CD300LF P261fsX266) are risk candidates for autism spectrum disorder. PMID: 25601189
The data suggest that the neuroprotective role of CD300f would be the result of a complex network of cell interactions. PMID: 21951326
peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling PMID: 22288587
CD300f blocked the activation of cells induced by all TLR ligands PMID: 22043923
Data indicate that CD300F is an active regulator of TLR-mediated macrophage activation through association with SHP-1 involving MyD88 and/or TRIF. PMID: 21536801
Findings indicate that IREM-1 exerted its inhibitory effect on BAFF-medicated signalling through ITIM-mediated regulation of ERK activities in THP-1 cells. PMID: 20646006
IgSF13 was identified from dendritic cells; preferentially expressed in myelo-monocytic cells, including monocytes, monocyte-derived DC and monocyte-related cell lines; may be involved in the negative regulation of specific leukocyte population [IgSF13] PMID: 15184070
a novel inhibitory receptor of the Ig superfamily in myeloid cells. (IREM-1 = immune receptor expressed on myeloid cells-1) PMID: 15549731
reveal a putative functional duality of the IREM-1 myeloid cell receptor PMID: 17202342

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

CD300 family

Tissue Specificity

Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocy

Database Links

HGNC: 29883

OMIM: 609807

KEGG: hsa:146722

STRING: 9606.ENSP00000327075

UniGene: Hs.567706

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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