CDH22 Antibody

Code CSB-PA050035
Size US$100
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Product Details

Uniprot No.
Target Names
CDH22
Alternative Names
CDH22 antibody; C20orf25 antibody; Cadherin-22 antibody; Pituitary and brain cadherin antibody; PB-cadherin antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human Cadherin-22.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.
Gene References into Functions
  1. cadherin-22 is upregulated in hypoxia via mTORC1-independent translational control by the initiation factor eIF4E2 functioning as a hypoxia-specific cell-surface molecule involved in cancer cell migration, invasion and adhesion. PMID: 28991229
  2. Results present evidence that CDH22 is hypermethylated and its expression is downregulated in breast cancer. PMID: 28149335
  3. PRL-3 promoted downregulation of CDH22 expression. PMID: 19440036
  4. Our results reveal for the first time a new role of CDH22 in progression of colorectal cancer. PMID: 19546606
  5. This paper deals primarily with the rat ortholog of the human CDH22 gene. PMID: 8626716

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Database Links

HGNC: 13251

OMIM: 609920

KEGG: hsa:64405

STRING: 9606.ENSP00000361336

UniGene: Hs.472861

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