CDKN2C Antibody

Code CSB-PA005094LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005094LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA005094LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CDKN2C Polyclonal antibody
Uniprot No.
Target Names
CDKN2C
Alternative Names
CDK6 inhibitor p18 antibody; CDKN 2C antibody; CDKN 6 antibody; Cdkn2c antibody; CDKN6 antibody; CDN2C_HUMAN antibody; Cyclin dependent inhibitor antibody; Cyclin dependent kinase 4 inhibitor C antibody; Cyclin dependent kinase 6 inhibitor antibody; Cyclin dependent kinase 6 inhibitor p18 antibody; Cyclin dependent kinase inhibitor 2C (p18 inhibits CDK4) antibody; Cyclin dependent kinase inhibitor 2C antibody; Cyclin-dependent kinase 4 inhibitor C antibody; Cyclin-dependent kinase 6 inhibitor antibody; INK4C antibody; OTTHUMP00000046546 antibody; p18 antibody; p18 inhibits CDK4 antibody; p18 INK4c antibody; p18 INK6 antibody; p18-INK4c antibody; p18-INK6 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cyclin-dependent kinase 4 inhibitor C protein (1-68AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CDKN2C Antibody (Product code: CSB-PA005094LA01HU) is Non-conjugated. For CDKN2C Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA005094LB01HU CDKN2C Antibody, HRP conjugated ELISA
FITC CSB-PA005094LC01HU CDKN2C Antibody, FITC conjugated
Biotin CSB-PA005094LD01HU CDKN2C Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Gene References into Functions
  1. Low P18 expression is associated with multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors. PMID: 29134609
  2. Cycling hypoxia could induce significant changes in CLDN1 and CLDN7 expression in nasopharyngeal cancer cells, indirectly regulation P18 expression and affecting cell invasion/proliferation. PMID: 28055967
  3. genetic association studies in population in Houston TX: Data suggest that CDKN2C copy number variations are associated with sporadic medullary thyroid carcinoma; these associations include presence of distant metastasis at presentation and decreased overall survival. PMID: 27610696
  4. CDKN2C gene deletion is associated with plasma cell post-transplantation lymphoproliferative disorders. PMID: 27750397
  5. Our study suggests that p18 is a limiting factor for the noncanonical HSC differentiation path in lymphoid lineages. PMID: 27287689
  6. CDKN2C inactivation contributes to the leukemogenesis in acute promyelocytic leukemia. PMID: 27888400
  7. DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18INK4C in gastric carcinogenesis PMID: 26350239
  8. Data suggest that cell cycle-dependent kinase inhibitors CDKN2C/p18 and CDKN1A/p21 facilitate cell cycle entry/cell proliferation of quiescent adult human pancreatic beta cells in primary culture (from tissues obtained from organ donors). PMID: 26740620
  9. Mutations in CDKN2C is associated with sporadic parathyroid adenoma. PMID: 24127162
  10. Analysis of B1a lymphocyte phenotypes of p18-deficient C57BL/6 mice finds that p18 is a key regulator of the size of the B1a cell pool. PMID: 22896639
  11. up-regulated HULC promotes proliferation of hepatoma cells through suppressing p18 PMID: 22685290
  12. Data indicate that the role of CDKN2C in the adverse outcome of cases with hemizygous deletion was less certain. PMID: 21994415
  13. results demonstrate for the first time that N-Myc is a downstream target of RET2A signaling, and propose that induction of N-Myc by RET2A is a key step leading to lower p18 levels during MEN2A tumorigenesis PMID: 21112821
  14. conclude that E2F proteins and Sp1 play an important role in the control of p18 expression PMID: 12077144
  15. Deletions in the CDKN2C locus and hypermethylation in the CDKN2C promoter region play a role in ovarian granulosa cell tumorogenesis. PMID: 12203782
  16. p18INK4c may function as a tumor suppressor in Hodgkin lymphoma, and inactivation may contribute to cell cycle deregulation and defective terminal differentiation of the Reed-Sternberg cells. PMID: 14645011
  17. protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c) PMID: 15107819
  18. p18(INK4C) loss may contribute to medulloblastoma formation in children PMID: 16260494
  19. oncogenic RET and loss of p18 cooperate in the multistep tumorigenesis of medullary thyroid carcinoma PMID: 18316595
  20. NaBu-mediated p18( INK4C ) regulation played a role in cell cycle arrest and erythroid differentiation in K562 cells. PMID: 18642058
  21. deletions of CDKN2C are important in the progression and clinical outcome of myeloma PMID: 18829482
  22. P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma PMID: 18942719
  23. Purpose was to investigate genetic alterations of CDKN2C gene in 38 pituitary adenomas. The absence of CDKN2C protein was correlated with LOH of the CDKN2C locus on chromosome 1 and with methylation of the CDKN2C promoter. PMID: 18973139
  24. The down-regulation of p18(INK4C) expression may contribute to the tumorigenesis of pituitary adenomas. PMID: 19401813
  25. p18(INK4C) is a downstream target of GATA3, constrains luminal progenitor cell expansion, and suppresses luminal tumorigenesis in the mammary gland PMID: 19411068
  26. Results identified a molecular basis for CDK inhibitors to exert an antitumor effect in p18-deficient cancers and support the clinical use of CDK inhibitors. PMID: 19509251

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Protein Families
CDKN2 cyclin-dependent kinase inhibitor family
Tissue Specificity
Highest levels found in skeletal muscle. Also found in pancreas and heart.
Database Links

HGNC: 1789

OMIM: 603369

KEGG: hsa:1031

STRING: 9606.ENSP00000262662

UniGene: Hs.525324

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