CENPB Antibody

1. Given that CENP-B is the only centromere protein that binds centromere-specific DNA elements, our study provides a new link between centromere DNA and unique epigenetic landscape of centromere chromatin PMID: 29273057
2. The results indicated that CENPB boxes are highly conserved in Down syndrome (DS) patients and may not be responsible for Chr21 nondisjunction events. However, alphasatDNA in Chr21 is variable and deoxynucleotide deletions, mutations and polymorphisms may act as potential molecular diagnostic markers of DS. PMID: 28259924
3. The results revealed that CENP-B binding in the vicinity of the CENP-A nucleosome substantially stabilizes the CENP-A nucleosome on alphoid DNA in human cells. PMID: 25916850
4. Centromere protein B (CENP-B) as a novel interacting partner of HBZ. PMID: 25281565
5. INMAP as a model regulator of CENP-B PMID: 24633075
6. N-terminal methylation is required for CENP-B's binding to the CENP-B box. PMID: 23978223
7. Human Nap1, an acidic histone chaperone, inhibited the non-specific binding of CENP-B to nucleosomes and apparently stimulated CENP-B binding to its cognate CENP-B box DNA. PMID: 23325853
8. Anti-CENP-B autoantibodies in breast cancer patients prolong disease-free and overall survival. PMID: 20222802
9. crystal structure of its dimerization domain (CENP-B-(540-599)), another functional domain of CENP-B, at 1.65-A resolution PMID: 14522975
10. the interaction between CENP-B and CENP-C may be involved in the correct assembly of CENP-C on alphoid DNA PMID: 14612452
11. CENP-B for the CENP-B box DNA is reduced nearly to the level of nonspecific DNA binding by CpG methylation PMID: 15634350
12. CENP-B may be a determinant for translational positioning of the centromere-specific nucleosomes through its binding to the nucleosomal CENP-B box PMID: 16183641
13. This study shows that ICP0 induces the proteasomal-dependent degradation of the centromeric protein CENP-B in infected as well as ICP0-expressing cells. PMID: 17258208
14. CENP-B was found to bind specifically to the surface of human pulmonary artery smooth muscle cells and not to fibroblasts or endothelial cells PMID: 17968937
15. observation of FRET between CENP-A and CENP-B at centromere locations; this indicates that these proteins are in the molecular vicinity (<10 nm) of each other PMID: 18072184
16. CENP-B binding stimulated the cross-talk between CCR3 and epidermal growth factor receptor (EGFR) in human pulmonary artery smooth muscle cells. PMID: 19714638
17. Study analyzed the distribution of PARP-1 and its interaction with CENP-B, -E, and -F during mitosis and apoptosis. PMID: 19723035

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HGNC: 1852

OMIM: 117140

KEGG: hsa:1059

STRING: 9606.ENSP00000369075

UniGene: Hs.516855