CEP70 Antibody

Code CSB-PA001585
Size US$100
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  • Western Blot analysis of COS7 cells using CEP70 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CEP70
Alternative Names
BITE antibody; Centrosomal protein of 70 kDa antibody; Cep70 antibody; CEP70_HUMAN antibody; p10 binding protein antibody; p10-binding protein antibody
Raised in
Rabbit
Species Reactivity
Human,Monkey
Immunogen
Synthesized peptide derived from the Internal region of Human CEP70.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Gene References into Functions
  1. Cep70 interacts with tubulin, and promotes the ability of paclitaxel to stimulate microtubule assembly. These data demonstrate that Cep70 mediates paclitaxel sensitivity in breast cancer. PMID: 28632150
  2. these results demonstrate a critical role for Cep70 in the development and progression of breast cancer. PMID: 28063737
  3. Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization PMID: 26893288
  4. findings suggest that Cep70 promotes microtubule stability by interaction with HDAC6 and regulation of tubulin acetylation PMID: 26112604
  5. data showed that Cep70 increased the microtubule length without affecting the microtubule number in the purified system; results demonstrate that Cep70 could directly regulate microtubule assembly by promoting microtubule elongation instead of microtubule nucleation PMID: 22427462
  6. These results thus report for the first time the identification of Cep70 as an important centrosomal protein that interacts with gamma-tubulin and underscore its critical role in the regulation of mitotic spindle assembly. PMID: 21795687

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Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.
Database Links

HGNC: 29972

OMIM: 614310

KEGG: hsa:80321

STRING: 9606.ENSP00000264982

UniGene: Hs.531962

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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