CHKB Antibody

Code CSB-PA001638
Size US$100
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  • Western Blot analysis of A549 cells using ChoKB Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CHKB
Alternative Names
CHETK antibody; Chetk-beta antibody; Chkb antibody; Chkb choline kinase beta antibody; Chkb protein antibody; CHKB_HUMAN antibody; CHKL antibody; Choline kinase beta antibody; Choline kinase-like antibody; Choline kinase-like protein antibody; Choline/ethanolamine kinase antibody; choline/ethanolamine kinase beta antibody; Choline/ethanolamine kinase; beta antibody; CK antibody; CK/EK antibody; CK/EK-beta antibody; CKB antibody; CKEKB antibody; EK antibody; EKB antibody; Ethanolamine kinase antibody; Ethanolamine kinase beta antibody; Ethanolamine kinase; beta antibody; MDCMC antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the C-terminal region of Human ChoKB.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis.
Gene References into Functions
  1. findings suggest that CKbeta, in concert with CKalpha, and depending on its phosphorylation status, might play a critical role as a druggable target in carcinogenesis PMID: 27149373
  2. The whole exome sequencing revealed a novel homozygous missense mutation in the Choline Kinase-Beta (CHKB) gene in exon 9. PMID: 27123443
  3. A new form of congenital muscular dystrophy with multisystem involvement and characteristic mitochondrial structural changes, due to choline kinase beta gene defects has been characterized. PMID: 26067811
  4. A novel silent variant in the choline kinase beta causing muscular dystrophy. PMID: 25740612
  5. Its mutations cause congenital muscular dystrophy.[Review] PMID: 24291895
  6. study identified a novel haplotype consisting of the indel variation, which had not been detected in previous studies in Japanese and Korean populations, and observed four single-nucleotide polymorphisms in CHKB/CPT1B PMID: 24571861
  7. CHKB encodes choline kinase beta, an enzyme that catalyzes the first de-novo biosynthetic step of phosphatidylcholine, the most abundant phospholipid in the eukaryotic membrane [review] PMID: 23945283
  8. CHKB activity was reduced in all three patients, significant reduction in choline:N-acetyl aspartate and choline:creatine ratios in keeping with a general decrease in the amount of choline and phosphocholine-based substrate PMID: 23692895
  9. The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B/CHKB (rs5770917) in the Chinese population. PMID: 22177342
  10. homozygous or compound heterozygous mutations in the gene encoding choline kinase beta were identified in individulas with congenital muscular dystrophy. PMID: 21665002
  11. A single nucleotide polymorphism located between CPT1B and CHKB, was associated with narcolepsy in Japanese (rs5770917[C], odds ratio (OR) = 1.79, combined P = 4.4 x 10(-7)) and other ancestry groups (OR = 1.40, P = 0.02). PMID: 18820697
  12. Japanese CNS hypersomnias (essential hypersomnia: EHS) other than narcolepsy with cataplexy was significantly associated with SNP rs5770917 (located between CPT1B and CHKB) and HLA-DRB1*1501-DQB1*0602 haplotype PMID: 19404393

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Protein Families
Choline/ethanolamine kinase family
Database Links

HGNC: 1938

OMIM: 612395

KEGG: hsa:1120

STRING: 9606.ENSP00000384400

UniGene: Hs.654827

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