CIZ1 Antibody

1. data reveal that CIZ1 plays a major role in ensuring stable association of Xist RNA within the Xi territory. PMID: 28923964
2. CIZ1 activates YAP/TAZ signaling in human hepatocellular carcinoma cells. PMID: 26515335
3. CIZ1 is a kinase sensor that promotes initiation of DNA replication at low kinase levels, when in a hypophosphorylated state that is permissive for cyclin-A-CDK2 interaction and delivery to licensed origins. PMID: 25736292
4. The results of this study showed CIZ1 will play a less important role in dystonia patient diagnosis than previously thought because variants of unclear significance are observed in approximately 1% of adult-onset sporadic dystonia patients in Germany. PMID: 25778706
5. Our study demonstrated that CIZ1 played an oncogenic role in the progression of GBC and CIZ1 might be a promising target for the treatment of GBC PMID: 25427641
6. This study suggested that No mutations in CIZ1 in twelve adult-onset primary cervical dystonia families. PMID: 23813719
7. CIZ1 may be involved in colon cancer progression by regulating cell proliferation, cell cycle, apoptosis and colony formation. PMID: 24126760
8. Variant Ciz1 is a strong candidate for a cancer-specific single marker capable of identifying early-stage lung cancer. PMID: 23074256
9. Mutations in CIZ1 may cause adult onset, primary cervical dystonia PMID: 22447717
10. alternatively spliced variant of Ciz1 is associated with cancer. PMID: 20831784
11. data indicate that Ciz1 is localized in the nucleus and is expressed in a wide range of tissues, especially the pancreas and the brain; formulated a consensus DNA sequence, ARYSR(0-2)YYAC, recognized by Ciz1 PMID: 12824700
12. Findings revealed the inherent role of Ciz1, a novel DNA binding and ER coactivator, in amplifying estrogenic responses and promoting breast cancer tumorigenesis. PMID: 17108141
13. conditional exclusion of exon 4 influences the spatial distribution of the Ciz1 protein within the nucleus, showing that CIZ1 alternative splicing could influence organized patterns of DNA replication PMID: 17508423
14. Ciz1 is a nuclear zinc finger protein interacting with p21, and is a DNA replication factor. The region of Ciz1 necessary for the interaction with ERH spans residues 531-644, encompassing its first zinc finger motif PMID: 18081865
15. An isoform of CIZ1 which lacks a glutamine-rich region, due to alternative splicing in exon 8, is upregulated in Alzheimer's brains relative to the full-length CIZ1 protein. PMID: 18583151

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HGNC: 16744

OMIM: 611420

KEGG: hsa:25792

STRING: 9606.ENSP00000362029

UniGene: Hs.212395