CLK4 Antibody

Code CSB-PA001719
Size US$100
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  • Western Blot analysis of HT29 cells using CLK4 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CLK4
Alternative Names
AI987988 antibody; C85119 antibody; CDC like kinase 4 antibody; CDC-like kinase 4 antibody; CLK4 antibody; CLK4_HUMAN antibody; DKFZp686A20267 antibody; Dual specificity protein kinase CLK4 antibody; OTTMUSP00000005756; antibody; OTTMUSP00000005757 antibody; OTTMUSP00000041113 antibody; Protein serine threonine kinase Clk4 antibody; RP23-9N7.1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human CLK4.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Gene References into Functions
  1. Clk1, Clk2 and Clk4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint. PMID: 27126587
  2. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. PMID: 19168442
Subcellular Location
Nucleus.
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily
Tissue Specificity
Expressed in liver, kidney, heart, muscle, brain and endothelial cells.
Database Links

HGNC: 13659

OMIM: 607969

KEGG: hsa:57396

STRING: 9606.ENSP00000316948

UniGene: Hs.406557

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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