CNDP2 Antibody

Datasheet

Code	CSB-PA856967HA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA856967HA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA856967HA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CNDP2 Polyclonal antibody

Uniprot No.

Q96KP4

Target Names

CNDP2

Alternative Names

0610010E05Rik antibody; C76600 antibody; Carnosinase ; tissue antibody; Carnosinase 2 antibody; CN 2 antibody; CN2 antibody; CNDP 2 antibody; CNDP dipeptidase 2 (metallopeptidase M20 family) antibody; CNDP dipeptidase 2 antibody; CNDP2 antibody; CNDP2_HUMAN antibody; CPGL antibody; Cytosolic non specific dipeptidase antibody; Cytosolic non-specific dipeptidase antibody; Cytosolic nonspecific dipeptidase antibody; Dip-2 antibody; FLJ10830 antibody; FLJ35544 antibody; Glutamate carboxypeptidase like protein 1 antibody; Glutamate carboxypeptidase-like protein 1 antibody; HsT2298 antibody; Nonspecific dipeptidase; cutosolic antibody; Pep-1 antibody; Pep1 antibody; PEPA antibody; Peptidase A antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cytosolic non-specific dipeptidase protein (2-475AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CNDP2 Antibody (Product code: CSB-PA856967HA01HU) is Non-conjugated. For CNDP2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA856967HB01HU	CNDP2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA856967HC01HU	CNDP2 Antibody, FITC conjugated
Biotin	CSB-PA856967HD01HU	CNDP2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way. Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism. Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis. Plays a role in the regulation of cell cycle arrest and apoptosis.

Gene References into Functions

The CNDP2 rs6566810 (A/A genotype) is overrepresented in endurance athletes, but only in international-level endurance athletes. Three SNPs (CNDP2 rs3764509, CNDP2-CNDP1 rs2346061, and CNDP1 rs2887) were overrepresented in power athletes compared with nonathletes. PMID: 28871847
These results suggest that the zinc form of CN2 is an active enzyme, but with a different substrate specificity from that of the manganese form. PMID: 29056506
To identify substrates of orphan transporter ATP-binding cassette subfamily C member 5 (ABCC5), identified a class of metabolites, N-lactoyl-amino acids, and found that a protease, cytosolic nonspecific dipeptidase 2 (CNDP2), catalyzes their formation. PMID: 25964343
Expression of CN2 in clinical colon tumors and colon cancer cell lines was significantly higher than that in normal colon mucosa cell lines. Knockdown of CNDP2 can inhibit the proliferation of colon cancer in vitro and retarded carcinogenesis in vivo. PMID: 24885395
Results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. PMID: 24395568
a key role of CNDP2 in PD neurodegeneration, by mechanisms that could involve oxidative stress, protein aggregation or inflammation. PMID: 22410244
deletion of the CPGL gene is a poor prognostic marker in resected pancreatic cancer, and functional studies suggest the CPGL gene as growth suppressor gene in pancreatic cancer. PMID: 22128300
Common variants in CNDP1 and CNDP2 play a role in susceptibility to kidney disease in patients with type 2 diabetes. PMID: 21573905
the crystal structure of the flop-selective allosteric modulator, PEPA, bound to the binding domains of the GluA2 and GluA3 flop isoforms of AMPA receptors PMID: 20199107
Our large, comprehensive study did not find an association between the D18S880 microsatellite or any other polymorphisms in the CNDP2-CNDP1 genomic region and susceptibility for diabetic nephropathy in type 1 diabetes PMID: 18753673

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Subcellular Location

Cytoplasm.

Protein Families

Peptidase M20A family

Tissue Specificity

[Isoform 1]: Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes. Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues (at protein level).; [Isoform 2]: Bro

Database Links

HGNC: 24437

OMIM: 169800

KEGG: hsa:55748

STRING: 9606.ENSP00000325548

UniGene: Hs.149185

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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