CNOT2 Antibody

Datasheet

Code	CSB-PA865193LA01HU
Size	US$166
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Image	Western blot All lanes: CNOT2 antibody at 2µg/ml Lane 1: 293T whole cell lysate Lane 2: Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 60, 41, 23, 52, 55 kDa Observed band size: 60 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CNOT2 Polyclonal antibody

Uniprot No.

Q9NZN8

Target Names

CNOT2

Alternative Names

CCR4 associated factor 2 antibody; CCR4 NOT transcription complex subunit 2 antibody; CCR4-associated factor 2 antibody; CCR4-NOT transcription complex subunit 2 antibody; CDC36 antibody; CNOT2 antibody; CNOT2_HUMAN antibody; HSPC131 antibody; MSTP046 antibody; Negative regulator of transcription 2 antibody; NOT2 (negative regulator of transcription 2 yeast) homolog antibody; NOT2 antibody; NOT2H antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human CCR4-NOT transcription complex subunit 2 protein (1-335AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CNOT2 Antibody (Product code: CSB-PA865193LA01HU) is Non-conjugated. For CNOT2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA865193LB01HU	CNOT2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA865193LC01HU	CNOT2 Antibody, FITC conjugated
Biotin	CSB-PA865193LD01HU	CNOT2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.

Gene References into Functions

CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells. PMID: 29024811
ERG is recruited to mRNAs via interaction with the RNA-binding protein RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. PMID: 27273514
The CNOT2-CNOT3 heterodimer is stabilized and tightly anchored to the surface of CNOT1 through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure. PMID: 24121232
Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs. PMID: 22367759
human CNOT2 is important for maintaining the deadenylase activity and structural integrity of the CCR4-NOT complex, thereby affecting cell viability. PMID: 21299754
This study shows that SMRT/NCoR-HDAC3 complex is a cofactor of CNOT2-mediated repression and suggests that transcriptional regulation by the Ccr4-Not complex involves regulation of chromatin modification. PMID: 16712523
major repression function of CNOT2 is localized in a specialized protein motif, the Not-Box PMID: 14707134
These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity. PMID: 16039607

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

CNOT2/3/5 family

Tissue Specificity

Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.

Database Links

HGNC: 7878

OMIM: 604909

KEGG: hsa:4848

STRING: 9606.ENSP00000229195

UniGene: Hs.133350

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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