CNPY2 Antibody

Code CSB-PA05034A0Rb
Size US$166
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Image
  • Western blot
    All lanes: CNPY2 antibody at 2µg/ml + 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/15000 dilution
    Predicted band size: 21, 10 kDa
    Observed band size: 47 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA05034A0Rb at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CNPY2 Polyclonal antibody
Uniprot No.
Target Names
CNPY2
Alternative Names
Canopy 2 homolog (zebrafish) antibody; Cnpy2 antibody; CNPY2_HUMAN antibody; MIR-interacting saposin-like protein antibody; MSAP antibody; Protein canopy homolog 2 antibody; Putative secreted protein ZSIG9 antibody; TMEM4 antibody; Transmembrane protein 4 antibody; UNQ1943/PRO4426 antibody; ZSIG9 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein canopy homolog 2 protein (22-182AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CNPY2 Antibody (Product code: CSB-PA05034A0Rb) is Non-conjugated. For CNPY2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA05034B0Rb CNPY2 Antibody, HRP conjugated ELISA
FITC CSB-PA05034C0Rb CNPY2 Antibody, FITC conjugated
Biotin CSB-PA05034D0Rb CNPY2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
Gene References into Functions
  1. CNPY2 knockout resulted in the significant suppression of MHCC97H cell proliferation, tumor growth, and hemorrhage. PMID: 30415246
  2. Overexpression of CNPY2 can activate the AKT/GSK3beta pathway, which leads to the inactivation of GSK-3beta. The inactivation of GSK-3beta increases the level of Snail, and then decreases the expression of E-cadherin to promote EMT. PMID: 29569784
  3. CNPY2 can serve as a therapeutic target to promote the effect of chemotherapy in non-small cell lung cancer. PMID: 29864955
  4. CNPY2 isoform2 represents as a novel and valuable prognostic indicator for colorectal cancer patients. PMID: 29135454
  5. These findings suggested that CNPY2 promoted cancer cell growth in renal cell carcinoma cells through regulating TP53 gene expression. PMID: 28235487
  6. CNPY2 may play a critical role in colorectal cancer development by enhancing cell proliferation, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 pathway PMID: 26835537
  7. CNPY2 is a HIF-1alpha-regulated, secreted angiogenic growth factor that promotes smooth muscle cell migration, proliferation, and tissue revascularization. PMID: 25589425
  8. Our results are consistent with an important role of FGF21 and Cnpy2/Msap in the regulation of LDLRs in cultured cells. PMID: 22378787
  9. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain in fetal and adult brain. PMID: 12826659

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Subcellular Location
Endoplasmic reticulum.
Protein Families
Canopy family
Tissue Specificity
Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.
Database Links

HGNC: 13529

OMIM: 605861

KEGG: hsa:10330

STRING: 9606.ENSP00000273308

UniGene: Hs.8752

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