COL16A1 Antibody

1. The NC11 domain of collagen XVI is a potential biomarker for oral squamous cell carcinoma and triggers vasculogenic mimicry via upregulation of endothelial receptors VEGFR1, VEGFR2 and uPAR. PMID: 26424749
2. High Collagen XVI expression is associated with invasion of oral squamous cell carcinoma. PMID: 24466237
3. collagen XVI plays a decisive role in the interaction of connective tissue cells with their ECM, which is impaired in pathological situations PMID: 23149016
4. Gene expression profiles showed that COL16A1 was up-regulated in epidermolysis bullosa subtypes. PMID: 22716248
5. Overexpression of type XVI collagen in aberrant oral keratinocytes leads to Kindlin-1 induction, increased Kindlin-1/beta1-integrin interaction, integrin activation and subsequently to a proliferative cellular phenotype. PMID: 21251976
6. Collagen XVI promotes persistence of intestinal subepithelial myofibroblasts in the normal and in the inflamed bowel wall by stabilizing focal adhesion contacts. PMID: 19931388
7. Not in banded collagen fibrils in dermis, but is component of specialized fibrillin-1-containing microfibrils. In cartilage matrix not in aggregates with fibrillin-1. Resides in thin, weakly banded collagen fibrils also containing collagens II and XI. PMID: 12782140
8. interacts with fibrillin-1 and with fibronectin indicating multiple molecular interactions in which this ubiquitously expressed and versatile fibril-associated collagens with interrupted triple helices-collagen can participate PMID: 15165854
9. These results demonstrate de-novo expression of collagen XVI in glioblastomas as part of the tumor specific remodeling of the ECM. PMID: 18804107

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HGNC: 2193

OMIM: 120326

KEGG: hsa:1307

STRING: 9606.ENSP00000362776

UniGene: Hs.368921