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CPNE1 Antibody

Datasheet
Code CSB-PA005900GA01HU
Size $600
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Product Details

Uniprot No.
Q99829
Target Names
CPNE1
Alternative Names
Copine 1 antibody; Copine I antibody; Copine-1 antibody; Copine1 antibody; CopineI antibody; COPN 1 antibody; COPN1 antibody; CPN 1 antibody; CPN1 antibody; CPNE 1 antibody; CPNE1 antibody; CPNE1_HUMAN antibody; MGC1142 antibody
Species Reactivity
Human,Mouse,Rat
Immunogen
Human CPNE1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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CPNE1 Antibodies

CPNE1 Proteins

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Target Background

Function
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.
Gene References into Functions
  1. Results demonstrated that CPNE1 was highly expressed in the osteosarcoma (OS) tissues and cell lines. Its knockdown significantly inhibited cell proliferation, colony formation, invasion and metastasis in OS cell lines. PMID: 29207139
  2. CPNE1 overexpression can upregulate TRAF2 expression in prostate cancer DU-145 cells as determined by Western blotting and immunofluorescence assays. PMID: 29151113
  3. Collectively, our findings suggest that JAB1 activates the neuronal differentiation ability of CPNE1 through the binding of C2A domain in CPNE1 with MPN domain in JAB1. PMID: 29448099
  4. Copine I regulates tumour necrosis factor-alpha receptor signaling pathways. PMID: 14674885
  5. Copine1 is upregulated in plasma membranes of TM cells in individuals with primary open-angle glaucoma. PMID: 18523666
  6. CPNE1 shares a promoter and 5'UTR exons with RBM12. This genomic structure is conserved among multiple species. PMID: 18831769

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Subcellular Location
Nucleus. Cytoplasm. Cell membrane.
Protein Families
Copine family
Tissue Specificity
Expressed in neutrophils (at protein level). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood.
Database Links

HGNC: 2314

OMIM: 604205

KEGG: hsa:8904

STRING: 9606.ENSP00000317257

UniGene: Hs.246413

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