CPNE1 Antibody, Biotin conjugated

Code CSB-PA859524LD01HU
Size US$299
Uniprot No. Q99829
Protocols ELISA Protocol
Immunogen Recombinant Human Copine-1 protein (326-537AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Copine-1 (Chromobindin 17) (Copine I), CPNE1, CPN1
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names CPNE1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes
Subcellular Location Nucleus, Cytoplasm, Cell membrane
Protein Families Copine family
Tissue Specificity Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241).
Database Links

HGNC: 2314

OMIM: 604205

KEGG: hsa:8904

STRING: 9606.ENSP00000317257

UniGene: Hs.246413

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