CSGALNACT1 Antibody

Datasheet

Code	CSB-PA953607
Size	US$297
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Image	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using CSGALNACT1 antibody.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CSGALNACT1 Polyclonal antibody

Uniprot No.

Q8TDX6

Target Names

CSGALNACT1

Alternative Names

4-N-acetylgalactosaminyltransferase 1 antibody; Beta4GalNAcT 1 antibody; beta4GalNAcT antibody; Beta4GalNAcT-1 antibody; Beta4GalNAcT1 antibody; CGAT1_HUMAN antibody; ChGn antibody; Chondroitin beta-1 antibody; Chondroitin beta1 4 N acetylgalactosaminyltransferase antibody; Chondroitin beta1 4 N acetylgalactosaminyltransferase 1 antibody; Chondroitin sulfate N acetylgalactosaminyltransferase 1 antibody; Chondroitin sulfate N-acetylgalactosaminyltransferase 1 antibody; CSGalNAcT 1 antibody; CsGalNAcT-1 antibody; Csgalnact1 antibody; FLJ11264 antibody; FLJ13760 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from internal of Human CSGALNACT1.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification. Moreover, is involved in the metabolism of aggrecan.

Gene References into Functions

In men, patients who had multiple sclerosis (MS) with S126L had a slower disease progression. This cSNP might be associated with the sex differences in clinical course of MS. PMID: 26806424
CSGalNAcT-1 and Hapln-1 may play important roles in the pathogenesis of Kashin-Beck disease and osteoarthritis. PMID: 23748413
CSGalNAcT-1 exhibited higher enzymatic efficiency toward monosulfated trisaccharides substituted at C4 or C6 position of Gal1, and at C6 of Gal2 compared with the unsulfated oligosaccharide. PMID: 22156920
CSGALNACT1 missense mutations are associated with neuropathies. PMID: 21160489
higher expression in the fetal skin than in adult skin PMID: 19701759
These results suggest that this enzyme has N-acetylgalactosaminyltransferase activity in both the elongation and initiation of chondroitin sulfate synthesis. PMID: 12163485

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Subcellular Location

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Protein Families

Chondroitin N-acetylgalactosaminyltransferase family

Tissue Specificity

Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.

Database Links

HGNC: 24290

OMIM: 616615

KEGG: hsa:55790

STRING: 9606.ENSP00000310891

UniGene: Hs.613729

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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