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CTDSP1 Antibody

Datasheet
Code CSB-PA131500
Size US$297
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Image
  • Western blot analysis of extracts from HUVEC cells and HeLa cells, using CTDSP1 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CTDSP1 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CTDSP1 Polyclonal antibody
Uniprot No.
Q9GZU7
Target Names
CTDSP1
Alternative Names
Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 1 antibody; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 antibody; CTD (carboxy terminal domain RNA polymerase II polypeptide A) small phosphatase 1 antibody; CTD small phosphatase 1 antibody; CTDS1_HUMAN antibody; CTDSP1 antibody; NIF3 antibody; NLI IF antibody; NLI interacting factor 3 antibody; NLI-IF antibody; NLI-interacting factor 3 antibody; NLIIF antibody; Nuclear LIM interactor interacting factor 3 antibody; Nuclear LIM interactor-interacting factor 3 antibody; SCP1 antibody; Small C-terminal domain phosphatase 1 antibody; Small CTD phosphatase 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from N-terminal of Human CTDSP1.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

CTDSP1 Antibodies

CTDSP1 Proteins

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Target Background

Function
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Gene References into Functions
  1. SCP1 is the phosphatase that counterregulates the MAPK-mediated phosphorylation of Ser(68)-Twist1. PMID: 26975371
  2. SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Serine-62. PMID: 25893300
  3. hSCP1 may be an beta-O-linked N-acetylglucosamine modified protein in vivo. PMID: 25081999
  4. CTDSP1 activity stabilizes REST in stem cells and ERK-dependent phosphorylation combined with Pin1 activity promotes REST degradation in neural progenitors. PMID: 25197063
  5. SCP1 phosphatase substrate specificity: CdcA3 could be an enzymatic substrate for SCP1. PMID: 24769477
  6. Captured the phosphoryl-aspartate intermediate in the crystal structure of a Scp1D206A mutant soaked with para-nitrophenyl phosphate (pNPP), providing strong evidence for the proposed mechanism. PMID: 20222012
  7. Polymorphisms vary significantly between races; Not associated with TB susceptibility in Caucasians. PMID: 11950066
  8. SCP1 may play a role in the regulation of gene expression, possibly by controlling the transition from initiation/capping to processive transcript elongation PMID: 12721286
  9. results show that REST/NRSF recruits SCPs to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells PMID: 15681389
  10. SCP1 acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 and Smad2. PMID: 17085434

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Subcellular Location
Nucleus. Note=Colocalizes with RNA polymerase II.
Tissue Specificity
Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
Database Links

HGNC: 21614

OMIM: 605323

KEGG: hsa:58190

STRING: 9606.ENSP00000273062

UniGene: Hs.444468

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