CYB5R4 Antibody

Code CSB-PA006321GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
CYB5R4
Alternative Names
b5+b5R antibody; b5b5r antibody; C79736 antibody; cb5/cb5R antibody; Cb5cb5r antibody; Cyb5r4 antibody; Cytochrome b type NAD(P)H oxidoreductase antibody; Cytochrome b5 reductase 4 antibody; dJ676J13.1 antibody; Flavohemoprotein b5+b5R antibody; Flavohemoprotein b5/b5R antibody; N terminal cytochrome b5 and cytochrome b5 oxidoreductase domain containing protein antibody; N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein antibody; NADPH cytochrome B5 oxidoreductase antibody; NB5R4_HUMAN antibody; NCB5OR antibody; RP4 676J13.1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human CYB5R4
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
Gene References into Functions
  1. Cytosolic localization of NADH cytochrome b oxidoreductase PMID: 26878259
  2. data provide first evidence for natural mutations in NCB5OR gene resulting in decreased protein levels and hence having potential implications in human pathology. PMID: 23523930
  3. Mutation in cytochrome b5 reductase is associated with developmental delay and severe neurological problems. PMID: 22627575
  4. Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain. PMID: 20630863
  5. NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum PMID: 15131110
  6. Variaation in the coding region is not a major contributor in the pathogenesis of nonautoimmune diabetes. PMID: 15504981

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Subcellular Location
Endoplasmic reticulum. Note=Soluble protein.
Protein Families
Flavoprotein pyridine nucleotide cytochrome reductase family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 20147

OMIM: 608343

KEGG: hsa:51167

STRING: 9606.ENSP00000358695

UniGene: Hs.5741

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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