CYP39A1 Antibody

Code CSB-PA882143LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: HEK293 whole cell lysate
    All lanes: CYP39A1 antibody at 3µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 55 kDa
    Observed band size: 55 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA882143LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA882143LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CYP39A1 Polyclonal antibody
Uniprot No.
Target Names
CYP39A1
Alternative Names
24 hydroxycholesterol 7 alpha hydroxylase antibody; 24-hydroxycholesterol 7-alpha-hydroxylase antibody; CP39A_HUMAN antibody; Cyp39a1 antibody; cytochrome P450 family 39; subfamily A polypeptide 1 antibody; Cytochrome P450 39A1 antibody; cytochrome P450 subfamily XXXIX (oxysterol 7 alpha hydroxylase) polypeptide 1 antibody; Cytochrome P450; family 39; subfamily a; polypeptide 1 antibody; hCYP39A1 antibody; Oxysterol 7 alpha hydroxylase antibody; Oxysterol 7-alpha-hydroxylase antibody; oxysterol 7alpha hydroxylase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 24-hydroxycholesterol 7-alpha-hydroxylase protein (235-392AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CYP39A1 Antibody (Product code: CSB-PA882143LA01HU) is Non-conjugated. For CYP39A1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA882143LB01HU CYP39A1 Antibody, HRP conjugated ELISA
FITC CSB-PA882143LC01HU CYP39A1 Antibody, FITC conjugated
Biotin CSB-PA882143LD01HU CYP39A1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Gene References into Functions
  1. The CYP39A1 polymorphism rs7761731 may help to identify patients at high risk for treatment related toxicity. PMID: 26475344
  2. GSTA1 and CYP39A1 were found to be associated with busulfan clearance. When combined, the two haplotypes explained 17% of the variability in busulfan clearance. PMID: 24192117
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Protein Families
Cytochrome P450 family
Tissue Specificity
Liver specific.
Database Links

HGNC: 17449

OMIM: 605994

KEGG: hsa:51302

STRING: 9606.ENSP00000275016

UniGene: Hs.387367

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