DDX23 Antibody

Code CSB-PA006613GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DDX23
Alternative Names
100 kDa U5 snRNP-specific protein antibody; DDX23 antibody; DDX23_HUMAN antibody; DEAD box protein 23 antibody; EC 3.6.1.- antibody; Probable ATP-dependent RNA helicase DDX23 antibody; PRP28 homolog antibody; U5-100kD antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human DDX23
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
Gene References into Functions
  1. These data provide new insights into the function of Prp28 in higher eukaryotes, and the requirements for stable tri-small nuclear ribonucleoproteins binding during B complex formation. PMID: 27377154
  2. new basis of DDX23-Linc00630-HDAC1 signal axis for understanding its pathogenicity, which could be further developed as a valuable therapeutic strategy PMID: 28473661
  3. pausing of RNA polymerase II (RNA Pol II) initiates a signaling cascade whereby the serine/arginine protein kinase 2 (SRPK2) phosphorylates the DDX23 helicase, culminating in the suppression of R-loops. PMID: 28076779
  4. SRPK2 knock down results in hypophosphorylation of the arginine-serine (RS) domain-containing human PRP28 protein (PRP28, also known as DDX23), and destabilizes PRP28 association with the tri-snRNP. PMID: 18425142
Subcellular Location
Nucleus. Chromosome.
Protein Families
DEAD box helicase family, DDX23/PRP28 subfamily
Database Links

HGNC: 17347

OMIM: 612172

KEGG: hsa:9416

STRING: 9606.ENSP00000310723

UniGene: Hs.130098

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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