DENND2D Antibody

Datasheet

Code	CSB-PA887987LA01HU
Size	US$166
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Image	Western blot All lanes: DENND2D antibody at 4µg/ml + MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 54 kDa Observed band size: 54 kDa Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA887987LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DENND2D Polyclonal antibody

Uniprot No.

Q9H6A0

Target Names

DENND2D

Alternative Names

2010308M01Rik antibody; AI451421 antibody; DEN2D_HUMAN antibody; DENN domain containing 2D antibody; DENN domain-containing protein 2D antibody; DENN/MADD domain containing 2D antibody; DENND2D antibody; FLJ22457 antibody; MGC6915 antibody; RGD1305120 antibody; RP5-1180E21.2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DENN domain-containing protein 2D protein (1-233AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DENND2D Antibody (Product code: CSB-PA887987LA01HU) is Non-conjugated. For DENND2D Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA887987LB01HU	DENND2D Antibody, HRP conjugated	ELISA
FITC	CSB-PA887987LC01HU	DENND2D Antibody, FITC conjugated
Biotin	CSB-PA887987LD01HU	DENND2D Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Gene References into Functions

resulted in increased cell motility and invasive ability. Moreover, miR-1246 increased cell motility by directly targeting DENN/MADD Domain Containing 2D (DENND2D) PMID: 27929118
Higher frequency of promoter hypermethylation of DENND2D is associated with gastric cancer. PMID: 24695972
DENND2D is a candidate tumor suppressor gene that was inactivated by promoter hypermethylation in patients with esophageal squamous cell carcinoma and may serve as a novel biomarker of esophageal squamous cell carcinoma. PMID: 24317529
DENND2D is a candidate tumor suppressor gene that is inactivated by promoter hypermethylation in patients with Hepatocellular carcinoma and may serve as a novel biomarker of early recurrence of Hepatocellular carcinoma . PMID: 24189587
Our data show that DENND2D might function as a tumor suppressor-like gene, preventing survival and expansion of cells with genetic damage through apoptosis mechanism. Absence of DENND2D might play a permissive role, as an early event, in tumorigenesis. PMID: 23182661
Mutations in DENND2D in melanoma by inhibition of nonsense-mediated mRNA decay. PMID: 18677770

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Subcellular Location

Cytoplasm.

Tissue Specificity

In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous lesions.

Database Links

HGNC: 26192

OMIM: 615111

KEGG: hsa:79961

STRING: 9606.ENSP00000350266

UniGene: Hs.557850

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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