DHPS Antibody

Datasheet

Code	CSB-PA006854LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006854LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DHPS Polyclonal antibody

Uniprot No.

P49366

Target Names

DHPS

Alternative Names

Deoxyhypusine synthase antibody; Dhps antibody; DHS antibody; DHYS_HUMAN antibody; DS antibody; MIG13 antibody; Migration inducing gene 13 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Deoxyhypusine synthase protein (1-94AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DHPS Antibody (Product code: CSB-PA006854LA01HU) is Non-conjugated. For DHPS Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA006854LB01HU	DHPS Antibody, HRP conjugated	ELISA
FITC	CSB-PA006854LC01HU	DHPS Antibody, FITC conjugated
Biotin	CSB-PA006854LD01HU	DHPS Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.

Gene References into Functions

the use of N1-Guanyl-1,7-diaminoheptane, a DHPS inhibitor, resulted in a significant decrease in tumor formation in vivo. In patients with esophageal squamous cell carcinoma (ESCC), overexpression of DHPS in ESCC tumors was significantly associated with worse recurrence-free survival, and correlated with distant metastasis. PMID: 27041563
Whereas, dhps mutation study revealed that triple mutant haplotype AGEAA (S436A+A437G+K540E) associated with Sulphadoxine resistance was found among 26% of P. falciparum field isolates. PMID: 25511211
eIF-5A as well as the hypusine-forming enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are highly overexpressed in glioblastoma patient sample PMID: 22927971
DHPS and WDR83 were capable of forming an RNA duplex at overlapping 3' untranslated regions and this duplex increased their mutual stability, which was required for the bidirectional regulation. PMID: 22491477
A novel series of cell movements that orient the polarity of Lrp12/Mig13a-expressing neurons and their axons just prior to cortical plate assembly do not occur in reeler mutant mice. PMID: 20439316
deoxyhypusine synthase has a role in generating spermidine or homospermidine PMID: 12788913
deoxyhypusine synthase and its phosphorylation modification may have other independent cellular functions because of versatile roles of deoxyhypusine synthase PMID: 14749535
crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex PMID: 15100216

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Protein Families

Deoxyhypusine synthase family

Database Links

HGNC: 2869

OMIM: 600944

KEGG: hsa:1725

STRING: 9606.ENSP00000210060

UniGene: Hs.79064

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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