DUSP26 Antibody

Datasheet

Code	CSB-PA863128LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA863128LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA863128LA01HU at dilution of 1:100 Immunofluorescence staining of SH-SY5Y cells with CSB-PA863128LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DUSP26 Polyclonal antibody

Uniprot No.

Q9BV47

Target Names

DUSP26

Alternative Names

DSP-4 antibody; Dual specificity phosphatase 26 (putative) antibody; Dual specificity phosphatase 26 antibody; Dual specificity phosphatase SKRP3 antibody; Dual specificity protein phosphatase 26 antibody; DUS26_HUMAN antibody; DUSP24 antibody; DUSP26 antibody; Hypothetical protein FLJ31142 antibody; LDP 4 antibody; LDP-4 antibody; Low molecular mass dual specificity phosphatase 4 antibody; Low-molecular-mass dual-specificity phosphatase 4 antibody; MAP kinase phosphatase 8 antibody; MGC1136 antibody; MGC2627 antibody; Mitogen activated protein kinase phosphatase 8 antibody; Mitogen-activated protein kinase phosphatase 8 antibody; MKP-8 antibody; MKP8 antibody; NATA1 antibody; NATA1 protein antibody; Novel amplified gene in thyroid anaplastic cancer antibody; SKRP3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Dual specificity protein phosphatase 26 protein (1-211AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DUSP26 Antibody (Product code: CSB-PA863128LA01HU) is Non-conjugated. For DUSP26 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA863128LB01HU	DUSP26 Antibody, HRP conjugated	ELISA
FITC	CSB-PA863128LC01HU	DUSP26 Antibody, FITC conjugated
Biotin	CSB-PA863128LD01HU	DUSP26 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).

Gene References into Functions

Enhanced expression of DUSP26 was observed in the hippocampus of Alzheimer's disease patients. PMID: 26924229
results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth. PMID: 24548998
The study reports the 1.68 A crystal structure of a catalytically inactive mutant (Cys152Ser) of DUSP26 lacking the first 60 N-terminal residues (DeltaN60-C/S-DUSP26). PMID: 23298255
DUSP26 may function as a tumour suppressor in particular cancers. PMID: 20347885
DUSP26 functions as a p53 phosphatase PMID: 20562916
DUSP26 effectively dephosphorylates p38 and has a little effect on extracellular signal-regulated kinase in anaplastic thyroid cancer. PMID: 16924234
Downregulation of Dusp26 may contribute to malignant phenotypes of glioma. PMID: 19043453

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Subcellular Location

Cytoplasm. Nucleus. Golgi apparatus.

Protein Families

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily

Tissue Specificity

Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.

Database Links

HGNC: 28161

KEGG: hsa:78986

STRING: 9606.ENSP00000256261

UniGene: Hs.8719

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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