ECEL1 Antibody

Code CSB-PA007373LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007373LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA007373LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA007373LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Immunofluorescent analysis of Hela cells using CSB-PA007373LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ECEL1 Polyclonal antibody
Uniprot No.
Target Names
ECEL1
Alternative Names
ECEL1; XCE; UNQ2431/PRO4991; Endothelin-converting enzyme-like 1; Xce protein
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Endothelin-converting enzyme-like 1 protein (425-775AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ECEL1 Antibody (Product code: CSB-PA007373LA01HU) is Non-conjugated. For ECEL1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA007373LB01HU ECEL1 Antibody, HRP conjugated ELISA
FITC CSB-PA007373LC01HU ECEL1 Antibody, FITC conjugated
Biotin CSB-PA007373LD01HU ECEL1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description
ECEL1 polyclonal antibody CSB-PA007373LA01HU was produced in the rabbit immunized by using the Recombinant Human Endothelin-converting enzyme-like 1 protein (425-775AA) as the immunogen. The target protein ECEL1 is a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Diseases associated with ECEL1 include Arthrogryposis, Distal, Type 5D and Distal Arthrogryposis.
This Rabbit anti-Homo sapiens (Human) ECEL1 Polyclonal antibody was tested in the IF, IHC and ELISA applications. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It only reacts with the ECEL1 proteins of human-origin and may be used to detect the endogenous levels of ECEL1 protein.

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Target Background

Function
May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.
Gene References into Functions
  1. Mutation of a conserved residue in ECEL1 is linked with fetal arthrogryposis multiplex congenita. PMID: 25708584
  2. Our clinical findings are consistent with recessive ECEL1 mutations causing variably penetrant orbital dysinnervation phenotypes (ptosis and/or complex strabismus with abnormal synkinesis) PMID: 25173900
  3. Three novel ECEL1 mutations have been identified in consanguineous pedigrees of Saudi Arabian origin presenting with distal arthrogryposis type 5D. PMID: 23829171
  4. A novel missense c.1819G>A mutation (G607S) in the ECEL1 gene has been identified in a consanguineous pedigree of Turkish origin presenting with congenital contracture syndromes. PMID: 23808592
  5. We described a new and homogenous phenotype of DA associated with ECEL1 that resulted in symptoms involving rather the peripheral than the central nervous system and suggesting a developmental dysfunction PMID: 23236030
  6. Mutations in ECEL1 cause distal arthrogryposis type 5D. PMID: 23261301
  7. Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the requisite synergistic effect in neuronal injury through DINE neuronal injury-inducible gene PMID: 18192274

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Involvement in disease
Arthrogryposis, distal, 5D (DA5D)
Subcellular Location
Membrane; Single-pass type II membrane protein.
Protein Families
Peptidase M13 family
Tissue Specificity
Highly expressed in the CNS, in particular in putamen, spinal cord, medulla and subthalamic nucleus. A strong signal was also detected in uterine subepithelial cells and around renal blood vessels. Detected at lower levels in amygdala, caudate, thalamus,
Database Links

HGNC: 3147

OMIM: 605896

KEGG: hsa:9427

STRING: 9606.ENSP00000302051

UniGene: Hs.26880

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