ERN2 Antibody

Datasheet

Code	CSB-PA006646
Size	US$119
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Product Details
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Target Background

Product Details

Uniprot No.

Q76MJ5

Target Names

ERN2

Alternative Names

ERN2 antibody; IRE2Serine/threonine-protein kinase/endoribonuclease IRE2 antibody; Endoplasmic reticulum-to-nucleus signaling 2 antibody; Inositol-requiring protein 2 antibody; hIRE2p antibody; Ire1-beta antibody; IRE1b) [Includes: Serine/threonine-protein kinase antibody; EC 2.7.11.1); Endoribonuclease antibody; EC 3.1.26.-)] antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the C-terminal region of Human IRE1α/β.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

IHC, IF, ELISA

Recommended Dilution

Application	Recommended Dilution
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:10000

Protocols

Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

Gene References into Functions

ER stress-regulated IRE1 dependent decay is involved in regulation of hepatic diseases. (review) PMID: 27774654
The luminal event mediated by IRE1beta involves direct interaction with unfolded proteins rather than association/dissociation with BiP. PMID: 23236464
Data show that IRE1beta represses translation on the ER membrane but not in the cytosol, and that this selective repression depends on the RNase activity of IRE1beta. PMID: 21146530
The structural, biochemical, and functional studies in vivo altogether demonstrate that IRE1 and PERK have conserved a common molecular interface necessary and sufficient for dimerization and unfolded protein response (UPR) signaling. PMID: 16973740
RNase domain of IRE1 determines the functional specificities of each of these isoforms. PMID: 18242182

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family

Database Links

HGNC: 16942

OMIM: 604034

KEGG: hsa:10595

STRING: 9606.ENSP00000256797

UniGene: Hs.592041

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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