EXOG Antibody

Datasheet

Code	CSB-PA007666ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA007666ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EXOG Polyclonal antibody

Uniprot No.

Q9Y2C4

Target Names

EXOG

Alternative Names

Endo G like 1 antibody; Endo G-like 1 antibody; Endo/exonuclease (5'-3'); endonuclease G like antibody; ENDOGL 1 antibody; ENDOGL1 antibody; ENDOGL2 antibody; Endonuclease G like 1 antibody; Endonuclease G like 2 antibody; Endonuclease G-like 1 antibody; ENGL a antibody; ENGL antibody; ENGL B antibody; ENGLA antibody; ENGLB antibody; Exog antibody; EXOG_HUMAN antibody; MGC125944 antibody; MGC125945 antibody; mitochondrial antibody; Nuclease EXOG antibody; Nuclease EXOG mitochondrial antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Nuclease EXOG, mitochondrial protein (144-368AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.

Gene References into Functions

Data suggest a role of exo/endonuclease G nuclease (hEXOG) in pathway for mitochondrial DNA repair. PMID: 28466855
These data indicate that HSV-1 UL12.5 deploys cellular proteins, including ENDOG and EXOG, to destroy mtDNA and contribute to a growing body of literature highlighting roles for ENDOG and EXOG in mtDNA maintenance. PMID: 23986585
EXOG depletion induces persistent SSBs in the mtDNA, enhances ROS levels, and causes apoptosis in normal cells but not in mt genome-deficient rho0 cells. PMID: 21768646
ENDOGL1 is a candidate disease-susceptibility gene for type 2 diabetes in a Japanese population PMID: 17415550
Human endonuclease G-like-1 is a dimeric mitochondrial enzyme that displays 5'-3' exonuclease activity and further differs from EndoG in substrate specificity PMID: 18187503

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Subcellular Location

Mitochondrion inner membrane.

Protein Families

DNA/RNA non-specific endonuclease family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 3347

OMIM: 604051

KEGG: hsa:9941

STRING: 9606.ENSP00000287675

UniGene: Hs.517897

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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