EXOG Antibody

Code CSB-PA002341
Size US$100
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  • Western Blot analysis of HuvEc cells using Endo G-L1 Polyclonal Antibody

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Product Details

Uniprot No.
Target Names
EXOG
Alternative Names
Endo G like 1 antibody; Endo G-like 1 antibody; Endo/exonuclease (5'-3'); endonuclease G like antibody; ENDOGL 1 antibody; ENDOGL1 antibody; ENDOGL2 antibody; Endonuclease G like 1 antibody; Endonuclease G like 2 antibody; Endonuclease G-like 1 antibody; ENGL a antibody; ENGL antibody; ENGL B antibody; ENGLA antibody; ENGLB antibody; Exog antibody; EXOG_HUMAN antibody; MGC125944 antibody; MGC125945 antibody; mitochondrial antibody; Nuclease EXOG antibody; Nuclease EXOG mitochondrial antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human Endo G-L1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.
Gene References into Functions
  1. Data suggest a role of exo/endonuclease G nuclease (hEXOG) in pathway for mitochondrial DNA repair. PMID: 28466855
  2. These data indicate that HSV-1 UL12.5 deploys cellular proteins, including ENDOG and EXOG, to destroy mtDNA and contribute to a growing body of literature highlighting roles for ENDOG and EXOG in mtDNA maintenance. PMID: 23986585
  3. EXOG depletion induces persistent SSBs in the mtDNA, enhances ROS levels, and causes apoptosis in normal cells but not in mt genome-deficient rho0 cells. PMID: 21768646
  4. ENDOGL1 is a candidate disease-susceptibility gene for type 2 diabetes in a Japanese population PMID: 17415550
  5. Human endonuclease G-like-1 is a dimeric mitochondrial enzyme that displays 5'-3' exonuclease activity and further differs from EndoG in substrate specificity PMID: 18187503

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Subcellular Location
Mitochondrion inner membrane.
Protein Families
DNA/RNA non-specific endonuclease family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 3347

OMIM: 604051

KEGG: hsa:9941

STRING: 9606.ENSP00000287675

UniGene: Hs.517897

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