EXTL3 Antibody

Datasheet

Code	CSB-PA03075A0Rb
Size	US$166
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Image	Western blot All lanes: EXTL3 antibody at 2µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted bane side: 105 kDa Observed band side: 105 kDa Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA03075A0Rb at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA03075A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EXTL3 Polyclonal antibody

Uniprot No.

O43909

Target Names

EXTL3

Alternative Names

botv antibody; DKFZp686C2342 antibody; Exostoses (multiple)-like 3 antibody; Exostoses-like 3 antibody; Exostosin-like 3 antibody; EXT-related protein 1 antibody; EXTL1L antibody; EXTL3 antibody; EXTL3_HUMAN antibody; EXTR1 antibody; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferas antibody; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase antibody; Hereditary multiple exostoses gene isolog antibody; KIAA0519 antibody; Multiple exostosis-like protein 3 antibody; Putative tumor suppressor protein EXTL3 antibody; REG antibody; Reg receptor antibody; REGR antibody; RPR antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Exostosin-like 3 protein (2-245AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The EXTL3 Antibody (Product code: CSB-PA03075A0Rb) is Non-conjugated. For EXTL3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA03075B0Rb	EXTL3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA03075C0Rb	EXTL3 Antibody, FITC conjugated
Biotin	CSB-PA03075D0Rb	EXTL3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation.

Gene References into Functions

Human lumenal N-glycosylated EXTL3 (EXTL3DeltaN) was cloned, expressed in human embryonic kidney cells, and purified. Various biophysical and biochemical approaches were then employed to elucidate the N-glycosylation sites and the function of their attached N-glycans. PMID: 29346724
EXTL3 missense mutation is associated with spondylo-epi-metaphyseal dysplasia. PMID: 28331220
EXTL3 mutations as a novel cause of severe immune deficiency with skeletal dysplasia and developmental delay and underline a crucial role of HS in thymopoiesis and skeletal and brain development. PMID: 28148688
We show that biallelic mutations in EXTL3 disturb glycosaminoglycan synthesis and thus lead to a recognizable syndrome characterized by variable expression of skeletal, neurological, and immunological abnormalities. PMID: 28132690
Recombinant EXTL2 showed weak ability to transfer N-acetylgalactosamine to heparan sulfate precursor molecules but also, that EXTL2 exhibited much stronger in vitro N-acetylglucosamine-transferase activity related to elongation of heparan sulfate chains. PMID: 25829497
Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor. PMID: 22158612
Lysosomal glycosaminoglycan levels in mucopolysaccharidosis are reduced by EXTL3 gene silencing. PMID: 19690583
We conclude that EXTL3 promoter methylation and its related loss of EXTL3 expression are involved in the loss of HS expression in mucinous CRCs. PMID: 18543267
HIP enhanced EXTL3 translocation from the membrane to the nucleus, in support of a model whereby EXTL3 mediates HIP signaling for islet neogenesis. PMID: 19158046
A missense mutation involving the exon 3 of the EXTL3 gene in the case of obstructing colon cancer is described in a 31-year-old patient affected by hereditary multiple exostoses. PMID: 19653241
These results suggest that EXTL3/EXTR1 is a cell surface Reg receptor that binds to Reg protein. PMID: 10753861

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Involvement in disease

Immunoskeletal dysplasia with neurodevelopmental abnormalities (ISDNA)

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus.

Protein Families

Glycosyltransferase 47 family

Tissue Specificity

Ubiquitous. Expressed in keratinocytes.

Database Links

HGNC: 3518

OMIM: 605744

KEGG: hsa:2137

STRING: 9606.ENSP00000220562

UniGene: Hs.491354

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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