FASTK Antibody

Code CSB-PA002483
Size US$100
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  • Western Blot analysis of A549 cells using FAST Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
FASTK
Alternative Names
Fas activated serine threonine kinase antibody; Fas-activated serine/threonine kinase antibody; FAST antibody; FAST kinase antibody; FASTK antibody; FASTK_HUMAN antibody; FLJ13079 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human FAST.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.; Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.
Gene References into Functions
  1. FASTK binds at multiple sites along the ND6 mRNA and its precursors and cooperates with the mitochondrial degradosome to ensure regulated ND6 mRNA biogenesis. PMID: 25704814
  2. MIR-106a-5p functions as a tumor suppressor during the development of astrocytomas by targeting FASTK. PMID: 24013584
  3. FAST expression on lung cells of hematopoietic origin is crucial in mediating lipopolysaccharide-induced neutrophil migration to the lung in transgenic FAST-deficient mice compared with wild type controls. PMID: 20363972
  4. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1 regulated changes in protein expression. PMID: 15572676
  5. FAST K synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing PMID: 17135269
  6. Nuclear FAST can regulate the splicing of FGFR2 transcripts. PMID: 17592127

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Subcellular Location
[Isoform 4]: Mitochondrion matrix.
Protein Families
FAST protein kinase family
Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Database Links

HGNC: 24676

OMIM: 606965

KEGG: hsa:10922

STRING: 9606.ENSP00000297532

UniGene: Hs.647094

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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