FLVCR2 Antibody

Datasheet

Code	CSB-PA892364ESR2HU
Size	US$166
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Image	Western blot All lanes: FLVCR2 antibody at 0.83µg/ml Lane 1: A549 whole cell lysate Lane 2: Mouse lung tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 58, 36 kDa Observed band size: 58 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA892364ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FLVCR2 Polyclonal antibody

Uniprot No.

Q9UPI3

Target Names

FLVCR2

Alternative Names

FLVCR2 antibody; C14orf58Feline leukemia virus subgroup C receptor-related protein 2 antibody; Calcium-chelate transporter antibody; CCT antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Feline leukemia virus subgroup C receptor-related protein 2 protein (1-100AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.

Gene References into Functions

Mutations in FLVCR2 associated with Fowler syndrome and survival beyond infancy PMID: 25677735
Mutations in FLVCR2 gene are responsible for Proliferative vasculopathy and Hydranencephaly-hydrocephaly syndrome. FLVCR2 transporter is gatekeeper for the controlled entry of calcium into cell, and involves the regulation of calcium metabolism. PMID: 25906927
FLVCR2 mutation is associated with Hydranencephaly. PMID: 25131804
High-throughput sequence data identified mutations and a large deletion in the FLVCR2 gene casuing lethal cerebral vasculopathy. PMID: 20690116
Results report the cellular function of FLVCR2 as an importer of heme. PMID: 20823265
Direct sequencing of candidate genes within the target interval in chromosome 14q24.3 revealed five different germline mutations in FLVCR2 in five families with Fowler syndrome. PMID: 20206334

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Involvement in disease

Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Major facilitator superfamily, Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family

Tissue Specificity

Expressed in non-hematopoietic tissues, with relative abundant expression in brain, placenta, lung, liver and kidney. Also expressed in hematopoietic tissues (fetal liver, spleen, lymph node, thymus, leukocytes and bone marrow). Found in acidophil cells o

Database Links

HGNC: 20105

OMIM: 225790

KEGG: hsa:55640

STRING: 9606.ENSP00000238667

UniGene: Hs.509966

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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